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nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial lifestyle interventions actually prescribed.

92 questions · sorted by votes · page 1 of 4

58 votes 3 answers37k views
Hair started shedding at month three. Does the timing tell me whether it is the drug or the weight loss?

Started tirzepatide in February. Nothing unusual until early June, when the shedding started, and it is now substantial: handfuls in the shower, hair on the pillow,…

hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

14 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
food-noise
food-noise

The reduction in intrusive, appetitive thinking about food that most people on the class describe. Its likely basis in central GLP-1R signalling,…

14 questions
asked by nadia_kowalczyk 14k · 2.0 years ago
53 votes 3 answers25k views
How much of the fatigue is actually drug-attributable, and what did the placebo arms report?

I am five months in, down 16 kg, and flattened. Not sleepy, exactly. More that everything costs more than it used to: stairs, conversations, training sessions I used…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

14 questions
asked by h_villanueva 50k · 22 months ago
43 votes 3 answers21k views
What protein target should I use, and is 130 g even geometrically possible inside 900 kcal?

I am 92.4 kg, female, 34, on tirzepatide 7.5 mg, and my logged intake has settled at roughly 900 kcal a day. I did not choose 900. It is what I eat when I eat until I…

protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

164 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by leonid_marchuk 15k · 16 months ago
39 votes5 answers31k views
How much protein in grams do I need at 95 kg on 1,000 kcal a day?

The particulars: 95 kg · 1,000 kcal. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online calculator…

protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

164 questions
asked by elke_brunner 14k · 2.1 years ago
39 votes 5 answers28k views
How do I tell vomiting from an energy deficit on 1,000 kcal a day?

Details up front: vomiting · 1,000 kcal. I have a result I cannot explain, and I would rather diagnose it than guess. I have checked the obvious explanations and…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
food-noise
food-noise

The reduction in intrusive, appetitive thinking about food that most people on the class describe. Its likely basis in central GLP-1R signalling,…

14 questions
asked by siobhan_deasy 16k · 2.4 years ago
39 votes 4 answers28k views
Five weeks with no scale movement at month five: how do I tell adaptive thermogenesis from adherence drift?

Month five, semaglutide 1.7 mg, and the scale has not moved in five weeks. Before that I was averaging about 0.5 kg a week fairly reliably. I am now at 88.1 kg from a…

plateau
plateau

A stall in progress: distinguishing adaptive thermogenesis from measurement error from adherence drift, how long to observe before changing…

35 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
cagrisema
cagrisema

A fixed-ratio combination of cagrilintide, a long-acting amylin analogue, with semaglutide, studied in the REDEFINE programme. Questions here…

14 questions
asked by nynke_dekker 18k · 15 months ago
39 votes5 answers23k views
How much protein in grams do I need at 81 kg on 1,200 kcal a day?

The specifics, since they change the answer: 81 kg · 1,200 kcal. I would rather understand the derivation than memorise the outcome. Two people I asked gave two…

protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

164 questions
sarcopenia
sarcopenia

Clinically meaningful loss of muscle mass and function, particularly in older adults on treatment. Distinguishing a proportional reduction from a…

14 questions
asked by swab_and_wait 15k · 2.0 years ago
38 votes0 answers30k views
How much protein in grams do I need at 124 kg on 1,000 kcal a day?

Numbers first: 124 kg · 1,000 kcal. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary; the method is…

protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

164 questions
asked by swab_stopper 16k · 19 months ago
38 votes5 answers24k views
How much protein in grams do I need at 112 kg on 1,100 kcal a day?

Conditions: 112 kg · 1,100 kcal. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as well as the…

protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

164 questions
asked by Dr_Ilse_Vandenberg 78k · 21 months ago
37 votes5 answers41k views
How do I tell fatigue from an energy deficit on 1,200 kcal a day?

The specifics, since they change the answer: fatigue · 1,200 kcal. Something has gone wrong and I would like to know how badly before I decide what to do. Nothing…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by day_seven_trough 11k · 2.1 years ago
37 votes 5 answers22k views
How much protein in grams do I need at 81 kg on 800 kcal a day?

The particulars: 81 kg · 800 kcal. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online calculator because…

protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

164 questions
asked by leah_ferrers 15k · 17 months ago
36 votes 3 answers38k views
How much protein in grams do I need at 81 kg on 1,100 kcal a day?

The case in front of me: 81 kg · 1,100 kcal. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as…

protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

164 questions
asked by anouk_desmet 18k · 2.2 years ago
36 votes 3 answers13k views
How much of my constipation is just eating 45% less? Working the arithmetic on residue and fluid

I want to check a hypothesis with numbers rather than argue about mechanisms. The claim I keep reading is that a large part of GLP-1 constipation is simply the…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

14 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
hydration
hydration

Fluid intake when thirst and intake cues are both blunted: how much of the early scale drop is fluid, how dehydration confounds a renal panel, and…

14 questions
protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
asked by lipid_panel_q 44k · 15 months ago
35 votes 5 answers25k views
How do I tell hair thinning from an energy deficit on 1,100 kcal a day?

Setup, so nobody has to ask: hair thinning · 1,100 kcal. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
gallbladder
gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug,…

14 questions
asked by tenth_of_a_unit 40k · 19 months ago
35 votes 2 answers24k views
How much protein in grams do I need at 88 kg on 1,100 kcal a day?

Concretely: 88 kg · 1,100 kcal. Please show the division. I want to check my own against yours. I would like the general form as well as the specific number, so I can…

protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

164 questions
asked by anders_vestby 17k · 15 months ago
32 votes 2 answers21k views
How much protein in grams do I need at 62 kg on 1,200 kcal a day?

The specifics, since they change the answer: 62 kg · 1,200 kcal. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used…

protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

164 questions
asked by noor_alhassan 15k · 14 months ago
32 votes3 answers9.8k views
How far did my sodium and potassium intake actually fall when my calories halved?

I would like to sanity-check the electrolyte question with numbers rather than by adding a supplement and seeing what happens. My hypothesis is that the reason people…

electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
hydration
hydration

Fluid intake when thirst and intake cues are both blunted: how much of the early scale drop is fluid, how dehydration confounds a renal panel, and…

14 questions
sarcopenia
sarcopenia

Clinically meaningful loss of muscle mass and function, particularly in older adults on treatment. Distinguishing a proportional reduction from a…

14 questions
asked by p_mkhize 41k · 2 months ago
32 votes 3 answers8.7k views
How do I quantify shedding well enough to know whether it is getting better or worse?

I am four months into a shedding episode and I genuinely cannot tell whether it is slowing down, stable or worse. My perception changes daily and is heavily…

hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

14 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
asked by tare_and_weigh 18k · 6 months ago
31 votes5 answers50k views
How much protein in grams do I need at 74 kg on 1,100 kcal a day?

Concretely: 74 kg · 1,100 kcal. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as well as the…

protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

164 questions
asked by eighty_six_hours 16k · 22 months ago
31 votes5 answers19k views
How much protein in grams do I need at 95 kg on 900 kcal a day?

Stated plainly: 95 kg · 900 kcal. I have worked this out and I would like someone to find the error, because I suspect there is one. My working so far, for the…

protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

164 questions
asked by stopper_core 50k · 17 months ago
30 votes 3 answers11k views
Does the leucine threshold matter if suppressed appetite means I only manage two meals a day?

I keep reading that muscle protein synthesis needs roughly 2.5-3 g of leucine per meal to fully trigger, and that you should distribute protein across three or four…

protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

164 questions
resistance-training
resistance-training

Loaded training as the primary intervention for retaining lean mass in a deficit: minimum effective dose, frequency versus volume, and why…

40 questions
asked by one_ml_bac 12k · 11 months ago
30 votes3 answers8.9k views
How do I tell a plateau from a new set point, and how long should I wait before changing anything?

Nine weeks flat at 71.6 kg, from a start of 94 kg. Semaglutide 2.4 mg, month fourteen. Intake weighed, not estimated, at 1,650 kcal. Steps averaging 9,400. Three…

plateau
plateau

A stall in progress: distinguishing adaptive thermogenesis from measurement error from adherence drift, how long to observe before changing…

35 questions
maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
hydration
hydration

Fluid intake when thirst and intake cues are both blunted: how much of the early scale drop is fluid, how dehydration confounds a renal panel, and…

14 questions
asked by rukhsana_iqbal 14k · 2 months ago
30 votes 2 answers8.2k views
How do I tell nausea from an energy deficit on 1,100 kcal a day?

Stated plainly: nausea · 1,100 kcal. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not discarded anything yet,…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by anders_vestby 17k · 11 months ago
29 votes5 answers44k views
How much protein in grams do I need at 88 kg on 900 kcal a day?

Setup, so nobody has to ask: 88 kg · 900 kcal. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of magnitude…

protein-intake
protein-intake

Protein targets in grams per kilogram, per-meal distribution and the leucine threshold, and the evidence for a higher intake specifically during…

53 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

164 questions
asked by ellis_thorne 17k · 17 months ago
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