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kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and dehydration as a confounder.

100 questions · sorted by votes · page 1 of 5

56 votes 3 answers32k views
At what point does vomiting on a GLP-1 agonist stop being a tolerability issue and become a clinical problem?

I have vomited three times in the last ten days, always in the twenty-four to forty-eight hours after my injection, always in the morning, and each time I felt…

vomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

14 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
hydration
hydration

Fluid intake when thirst and intake cues are both blunted: how much of the early scale drop is fluid, how dehydration confounds a renal panel, and…

14 questions
asked by nine_point_nine 45k · 21 months ago
49 votes 3 answers23k views
My creatinine is up and eGFR down after two bad weeks. How much of that is dehydration rather than kidney damage?

Background: eight months on tirzepatide, uneventful until a bad fortnight of vomiting and diarrhoea after a dose increase, during which I ate very little and drank…

kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
vomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

14 questions
hydration
hydration

Fluid intake when thirst and intake cues are both blunted: how much of the early scale drop is fluid, how dehydration confounds a renal panel, and…

14 questions
asked by mg_per_ml 12k · 4 months ago
41 votes 5 answers44k views
Why did my albumin-to-creatinine ratio move after sixteen weeks on tirzepatide?

Details up front: albumin-to-creatinine ratio · sixteen weeks · tirzepatide. I have a result I cannot explain, and I would rather diagnose it than guess. I have…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by v_ramaswamy 40k · 2.2 years ago
41 votes 3 answers14k views
When is a blood panel actually worth drawing during rapid loss, and which markers are uninterpretable while losing?

I have been offered "a full panel" and I would rather understand what I am asking for than collect numbers I cannot interpret. My concern is specifically that active…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
asked by two_point_four 14k · 9 months ago
40 votes 5 answers36k views
Is LDL-C a better monitoring choice than triglycerides on semaglutide?

Stated plainly: LDL-C · triglycerides · semaglutide. Both of these get recommended confidently by different people, which suggests neither is obviously right. My…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by juliette_farnese 12k · 2.0 years ago
35 votes 5 answers43k views
Why did my LDL-C move after eight weeks on ecnoglutide?

Setup, so nobody has to ask: LDL-C · eight weeks · ecnoglutide. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by tobias_maartens 94k · 18 months ago
35 votes5 answers21k views
Is ferritin a better monitoring choice than ApoB on retatrutide?

The case in front of me: ferritin · ApoB · retatrutide. I would like the axes of comparison first and the recommendation second. I have tried the first option and it…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by tare_weight 47k · 17 months ago
34 votes0 answers37k views
Is ALT a better monitoring choice than AST on semaglutide?

Stated plainly: ALT · AST · semaglutide. Both of these get recommended confidently by different people, which suggests neither is obviously right. My constraints are…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by Dr_Marek_Zielinski 39k · 23 months ago
34 votes 5 answers29k views
Is lipase a better monitoring choice than potassium on survodutide?

Stated plainly: lipase · potassium · survodutide. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can obtain…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by greta_holzmann 15k · 16 months ago
34 votes 5 answers17k views
Is TSH a better monitoring choice than magnesium on oral semaglutide?

Details up front: TSH · magnesium · oral semaglutide. I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by ahmed_zerouali 19k · 17 months ago
34 votes 3 answers7k views
Why is albuminuria described as more informative than eGFR at a normal eGFR?

My eGFR is 92 and has been for years, which I had taken to mean my kidneys were not a topic. A urine albumin:creatinine ratio was added to a recent panel and came…

kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
renal-outcomes
renal-outcomes

Kidney endpoints: the FLOW composite, eGFR slope as an endpoint, albuminuria regression, and why an early eGFR dip is expected rather than alarming.

14 questions
bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by bea_castellanos 47k · 4 months ago
33 votes5 answers48k views
Why did my ApoB move after sixteen weeks on oral semaglutide?

Numbers first: ApoB · sixteen weeks · oral semaglutide. I have a result I cannot explain, and I would rather diagnose it than guess. I have checked the obvious…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by mateo_iglesias 16k · 18 months ago
32 votes 5 answers65k views
Why did my TSH move after six weeks on oral semaglutide?

Numbers first: TSH · six weeks · oral semaglutide. Before I write this off, I want to check whether it is a known failure mode. I have the lot number, the certificate…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by nadia_kowalczyk 14k · 2.3 years ago
32 votes 5 answers55k views
Why did my ApoB move after sixteen weeks on tirzepatide?

What I have: ApoB · sixteen weeks · tirzepatide. I have a result I cannot explain, and I would rather diagnose it than guess. I have checked the obvious explanations…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by jonas_ekstrom 18k · 21 months ago
32 votes0 answers35k views
Is AST a better monitoring choice than ALT on a GLP-1 receptor agonist?

The specifics, since they change the answer: AST · ALT · a GLP-1 receptor agonist. The comparison I want does not seem to exist anywhere in a form I can evaluate. I…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by tare_weight 47k · 20 months ago
32 votes0 answers27k views
Why did my AST move after ten weeks on a GLP-1 receptor agonist?

The specifics, since they change the answer: AST · ten weeks · a GLP-1 receptor agonist. Something has gone wrong and I would like to know how badly before I decide…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by zainab_mustafa 16k · 19 months ago
32 votes 3 answers15k views
Which blood panels are actually worth ordering on a GLP-1, and at what interval?

I have been offered a "metabolic optimisation panel" by a private lab that runs to 58 analytes and costs about the same as a month of compounded semaglutide. My GP…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
a1c
a1c

Glycated haemoglobin as a ninety-day glycaemic average: what a change of half a point means, why it lags, and the conditions under which it…

108 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by mass_shift_18 14k · 23 months ago
32 votes 3 answers15k views
My eGFR fell from 85 to 74 eight weeks in. Is that the expected dip or actual injury?

Male, 52, baseline creatinine 1.05 mg/dL with a reported eGFR of 85. Eight weeks into semaglutide, after two escalations, creatinine 1.18 mg/dL and eGFR 74. No…

kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
hydration
hydration

Fluid intake when thirst and intake cues are both blunted: how much of the early scale drop is fluid, how dehydration confounds a renal panel, and…

14 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by Dr_Lena_Ostrowska 42k · 21 months ago
32 votes 3 answers11k views
When does HbA1c lie? My A1c dropped 0.7 with no change in my CGM average

Two data streams disagreeing, and I cannot reconcile them. Over eleven weeks my HbA1c fell from 7.1% to 6.4%. Over the same eleven weeks my sensor mean glucose was…

a1c
a1c

Glycated haemoglobin as a ninety-day glycaemic average: what a change of half a point means, why it lags, and the conditions under which it…

108 questions
bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
t2dm
t2dm

Type 2 diabetes: glycaemic endpoints, the SURPASS and SUSTAIN programmes, dose ranges licensed for diabetes versus obesity, and interaction with…

20 questions
asked by seamus_brady 17k · 11 months ago
31 votes 5 answers53k views
Why did my lipase move after two weeks on semaglutide?

Stated plainly: lipase · two weeks · semaglutide. This is not behaving the way I expected and I want to understand the discrepancy before I act on it. I have…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by bounty_hunter_q 18k · 23 months ago
31 votes 5 answers24k views
Is potassium a better monitoring choice than lipase on mazdutide?

The particulars: potassium · lipase · mazdutide. I am trying to choose between two options that are usually discussed as though only one exists. I am not optimising…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by tess_amankwah 48k · 13 months ago
30 votes5 answers38k views
Is GGT a better monitoring choice than albumin-to-creatinine ratio on orforglipron?

Concretely: GGT · albumin-to-creatinine ratio · orforglipron. I would like the axes of comparison first and the recommendation second. I have tried the first option…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by gel_pack_warm 13k · 16 months ago
30 votes 5 answers27k views
Why did my eGFR move after six weeks on tirzepatide?

Numbers first: eGFR · six weeks · tirzepatide. Before I write this off, I want to check whether it is a known failure mode. I have the lot number, the certificate and…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by drawn_and_capped 15k · 10 months ago
30 votes 5 answers21k views
Is cystatin C a better monitoring choice than creatinine on a GLP-1 receptor agonist?

For reference: cystatin C · creatinine · a GLP-1 receptor agonist. I am trying to choose between two options that are usually discussed as though only one exists. I…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
lipids
lipids

Lipid response on treatment: triglycerides, LDL-C, non-HDL-C, ApoB and Lp(a), which of them move with weight loss, and why a fasting panel drawn…

112 questions
asked by two_point_four 14k · 17 months ago
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