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electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing, and the limits of supplementation.

36 questions · sorted by votes · page 1 of 2

53 votes 3 answers25k views
How much of the fatigue is actually drug-attributable, and what did the placebo arms report?

I am five months in, down 16 kg, and flattened. Not sleepy, exactly. More that everything costs more than it used to: stairs, conversations, training sessions I used…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

14 questions
asked by h_villanueva 50k · 22 months ago
41 votes 3 answers14k views
When is a blood panel actually worth drawing during rapid loss, and which markers are uninterpretable while losing?

I have been offered "a full panel" and I would rather understand what I am asking for than collect numbers I cannot interpret. My concern is specifically that active…

bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
asked by two_point_four 14k · 9 months ago
39 votes 5 answers28k views
How do I tell vomiting from an energy deficit on 1,000 kcal a day?

Details up front: vomiting · 1,000 kcal. I have a result I cannot explain, and I would rather diagnose it than guess. I have checked the obvious explanations and…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
food-noise
food-noise

The reduction in intrusive, appetitive thinking about food that most people on the class describe. Its likely basis in central GLP-1R signalling,…

14 questions
asked by siobhan_deasy 16k · 2.4 years ago
37 votes5 answers41k views
How do I tell fatigue from an energy deficit on 1,200 kcal a day?

The specifics, since they change the answer: fatigue · 1,200 kcal. Something has gone wrong and I would like to know how badly before I decide what to do. Nothing…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by day_seven_trough 11k · 2.1 years ago
35 votes 5 answers25k views
How do I tell hair thinning from an energy deficit on 1,100 kcal a day?

Setup, so nobody has to ask: hair thinning · 1,100 kcal. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
gallbladder
gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug,…

14 questions
asked by tenth_of_a_unit 40k · 19 months ago
32 votes3 answers9.8k views
How far did my sodium and potassium intake actually fall when my calories halved?

I would like to sanity-check the electrolyte question with numbers rather than by adding a supplement and seeing what happens. My hypothesis is that the reason people…

electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
hydration
hydration

Fluid intake when thirst and intake cues are both blunted: how much of the early scale drop is fluid, how dehydration confounds a renal panel, and…

14 questions
sarcopenia
sarcopenia

Clinically meaningful loss of muscle mass and function, particularly in older adults on treatment. Distinguishing a proportional reduction from a…

14 questions
asked by p_mkhize 41k · 2 months ago
31 votes0 answers48k views
Which electrolyte shortfall presents as fatigue first?

Scale weight, waist circumference and a repetition maximum, all logged weekly. I would like to know the limits of what can be inferred from this. What I am trying to…

electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
hydration
hydration

Fluid intake when thirst and intake cues are both blunted: how much of the early scale drop is fluid, how dehydration confounds a renal panel, and…

14 questions
asked by oona_kekkonen 16k · 2.3 years ago
30 votes 2 answers8.2k views
How do I tell nausea from an energy deficit on 1,100 kcal a day?

Stated plainly: nausea · 1,100 kcal. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not discarded anything yet,…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by anders_vestby 17k · 11 months ago
29 votes 4 answers33k views
How do I tell headache from an energy deficit on 1,400 kcal a day?

Concretely: headache · 1,400 kcal. I think I have a problem. I am not yet sure whether it is a real problem or a measurement artefact. I want to know whether this is…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by jo_vandeberg 19k · 23 months ago
27 votes 5 answers16k views
How do I tell headache from an energy deficit on 1,100 kcal a day?

Stated plainly: headache · 1,100 kcal. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not discarded anything yet,…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
injection-site-reaction
injection-site-reaction

Local reactions: erythema, induration, pruritus and nodules. Their relationship to injection depth, diluent composition, benzyl alcohol…

14 questions
gallbladder
gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug,…

14 questions
asked by eighty_six_hours 16k · 16 months ago
26 votes 5 answers5.2k views
How do I tell reflux from an energy deficit on 1,200 kcal a day?

Numbers first: reflux · 1,200 kcal. I have a result I cannot explain, and I would rather diagnose it than guess. I have checked the obvious explanations and…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

14 questions
asked by drawn_and_capped 15k · 5 months ago
25 votes 5 answers21k views
How do I tell constipation from an energy deficit on 900 kcal a day?

Conditions: constipation · 900 kcal. I think I have a problem. I am not yet sure whether it is a real problem or a measurement artefact. I want to know whether this…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
injection-site-reaction
injection-site-reaction

Local reactions: erythema, induration, pruritus and nodules. Their relationship to injection depth, diluent composition, benzyl alcohol…

14 questions
asked by yuki_morishita 19k · 17 months ago
23 votes 5 answers26k views
How do I tell constipation from an energy deficit on 1,400 kcal a day?

Setup, so nobody has to ask: constipation · 1,400 kcal. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by ivo_paunovic 15k · 22 months ago
22 votes0 answers24k views
How do I tell early satiety from an energy deficit on 1,400 kcal a day?

Setup, so nobody has to ask: early satiety · 1,400 kcal. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by ilaria_bertone 43k · 18 months ago
21 votes 5 answers30k views
How do I tell fatigue from an energy deficit on 800 kcal a day?

Numbers first: fatigue · 800 kcal. Before I write this off, I want to check whether it is a known failure mode. I have the lot number, the certificate and the date,…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by coldbox9 13k · 23 months ago
21 votes0 answers16k views
How do I tell reflux from an energy deficit on 800 kcal a day?

For reference: reflux · 800 kcal. Something has gone wrong and I would like to know how badly before I decide what to do. Nothing else in the setup changed, which is…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by nkem_obiora 46k · 2.3 years ago
21 votes 4 answers11k views
How do I tell injection-site erythema from an energy deficit on 1,000 kcal a day?

What I have: injection-site erythema · 1,000 kcal. I have a result I cannot explain, and I would rather diagnose it than guess. I have checked the obvious…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by valentina_rossi 16k · 4 months ago
21 votes0 answers9.8k views
How much fluid is enough when thirst cues are blunted?

The trend is what I care about; individual weeks are obviously noise. I would like to understand the steps well enough to explain them to someone else. I have access…

hydration
hydration

Fluid intake when thirst and intake cues are both blunted: how much of the early scale drop is fluid, how dehydration confounds a renal panel, and…

14 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

100 questions
sleep-apnea
sleep-apnea

Obstructive sleep apnoea and the apnoea-hypopnoea index response to weight loss, including the SURMOUNT-OSA dataset and the question of whether…

14 questions
asked by Dr_Malik_Osei 37k · 10 months ago
21 votes 5 answers6.5k views
How do I tell constipation from an energy deficit on 1,100 kcal a day?

Setup, so nobody has to ask: constipation · 1,100 kcal. This is not behaving the way I expected and I want to understand the discrepancy before I act on it. I have…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by leah_ferrers 15k · 8 months ago
20 votes 2 answers7.5k views
How do I tell headache from an energy deficit on 900 kcal a day?

Stated plainly: headache · 900 kcal. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not discarded anything yet,…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
sarcopenia
sarcopenia

Clinically meaningful loss of muscle mass and function, particularly in older adults on treatment. Distinguishing a proportional reduction from a…

14 questions
asked by rota_site 55k · 7 months ago
18 votes 5 answers38k views
How do I tell nausea from an energy deficit on 900 kcal a day?

Concretely: nausea · 900 kcal. I have two candidate explanations and no way to distinguish them. The same procedure has worked without incident several times…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by label_claim 11k · 21 months ago
18 votes5 answers16k views
How do I tell early satiety from an energy deficit on 1,100 kcal a day?

Concretely: early satiety · 1,100 kcal. I have two candidate explanations and no way to distinguish them. The same procedure has worked without incident several times…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by felix_araya 17k · 23 months ago
18 votes 5 answers6.4k views
How do I tell reflux from an energy deficit on 1,000 kcal a day?

For reference: reflux · 1,000 kcal. An unexpected observation, and I would like a differential rather than reassurance. The conditions were within what I understood…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by anouk_desmet 18k · 29 days ago
17 votes 2 answers32k views
How do I tell injection-site erythema from an energy deficit on 1,200 kcal a day?

What I have: injection-site erythema · 1,200 kcal. Before I write this off, I want to check whether it is a known failure mode. I have the lot number, the certificate…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

38 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

36 questions
asked by olu_babatunde 14k · 2.3 years ago
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