Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition substudies in the major programmes, and how to read your own scan sequence.
The claim that "about a quarter of what you lose on these drugs is muscle" gets repeated everywhere and I have never once seen it sourced. I am 14 weeks into…
Down 19 kg over seven months on semaglutide. My DEXA says I have lost 1.4 kg of lean soft tissue, which everyone tells me is a good result. But in the gym I am…
I am 92.4 kg, female, 34, on tirzepatide 7.5 mg, and my logged intake has settled at roughly 900 kcal a day. I did not choose 900. It is what I eat when I eat until I…
I have added a lot of cardio because it felt like the responsible thing to do and now I am not sure it is helping. Current week: three full-body lifting sessions,…
For reference: liraglutide · SURPASS-3. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am…
The case in front of me: twelve · 1,400 kcal. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow the plan I…
Numbers first: mazdutide · STEP 2. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree,…
The particulars: 95 kg · 1,000 kcal. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online calculator…
The specifics, since they change the answer: 81 kg · 1,200 kcal. I would rather understand the derivation than memorise the outcome. Two people I asked gave two…
Setup, so nobody has to ask: retatrutide · PIONEER-1. I have read the primary source rather than the summary, which has left me with more questions. I understand the…
Numbers first: 124 kg · 1,000 kcal. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary; the method is…
The trend is what I care about; individual weeks are obviously noise. I want to understand what this actually establishes, as opposed to what it is being used to…
Conditions: 112 kg · 1,100 kcal. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as well as the…
Stated plainly: retatrutide · STEP 4. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline. I do…
The particulars: oral semaglutide · STEP 2. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…
What I have: eight · 1,000 kcal. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the minimum viable version,…
I want the floor, not the optimum. I am losing about 0.9 kg a week on tirzepatide and I have limited capacity to train: realistically two sessions a week, 40 minutes…
The particulars: 81 kg · 800 kcal. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online calculator because…
Intake is tracked, imperfectly, and I am aware of the direction of the error. I suspect the honest answer is that it depends, in which case I would like to know on…
The case in front of me: 81 kg · 1,100 kcal. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as…
The case in front of me: survodutide · SURMOUNT-4. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a…
The particulars: liraglutide · TRIUMPH-1. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am…
The case in front of me: survodutide · SUSTAIN-6. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a…
Concretely: 88 kg · 1,100 kcal. Please show the division. I want to check my own against yours. I would like the general form as well as the specific number, so I can…
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