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dead-space

Page 2 of 5 · 110 questions tagged dead-space.

110 questions · sorted by votes · page 2 of 5

29 votes 5 answers36k views
Why does a 0.3 mL insulin syringe read differently from the volume I thought I drew at 2.5 mg/mL?

For reference: a 0.3 mL insulin syringe · 2.5 mg/mL. An unexpected observation, and I would like a differential rather than reassurance. The conditions were within…

insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by w_okoye 40k · 18 months ago
28 votes5 answers39k views
Is a 31G needle the right choice for drawing ecnoglutide at 20 mg/mL?

For reference: a 31G needle · ecnoglutide · 20 mg/mL. The comparison I want does not seem to exist anywhere in a form I can evaluate. I have read the arguments for…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

85 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

90 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
asked by area_percent 13k · 21 months ago
28 votes 5 answers23k views
Why does a 1 mL luer-lock syringe read differently from the volume I thought I drew at 1 mg/mL?

The specifics, since they change the answer: a 1 mL luer-lock syringe · 1 mg/mL. An unexpected observation, and I would like a differential rather than reassurance.…

insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by rania_haddad 17k · 20 months ago
28 votes0 answers20k views
Is a 29G needle the right choice for drawing survodutide at 20 mg/mL?

The specifics, since they change the answer: a 29G needle · survodutide · 20 mg/mL. The comparison I want does not seem to exist anywhere in a form I can evaluate. I…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

85 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

90 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
asked by dana_wexler 15k · 2.3 years ago
27 votes5 answers16k views
Why does a low-dead-space syringe read differently from the volume I thought I drew at 3.33 mg/mL?

Stated plainly: a low-dead-space syringe · 3.33 mg/mL. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not…

insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by assay_blank 39k · 19 months ago
26 votes 3 answers25k views
What does splitting a weekly dose actually cost in vial entries and compounded measurement error?

Most discussion of splitting a weekly dose treats the costs as vague — "more injections", "more chances for contamination". I would like the costs quantified, because…

split-dosing
split-dosing

Dividing a weekly dose across more than one administration. Questions here concern the pharmacokinetic rationale, whether the peak-to-trough ratio…

39 questions
sterility
sterility

Sterility as a test result rather than an adjective. Covers what a sterility test actually measures, why "sterile filtered" on a document is close…

122 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
asked by orla_sheridan 14k · 13 months ago
25 votes 5 answers39k views
Is a 25G drawing needle the right choice for drawing liraglutide at 10 mg/mL?

The case in front of me: a 25G drawing needle · liraglutide · 10 mg/mL. I would like the axes of comparison first and the recommendation second. I have tried the…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

85 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

90 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
asked by ruaidhri_o_shea 51k · 19 months ago
25 votes 5 answers24k views
What is the real cost per milligram after dead-space loss?

I am comparing three suppliers on documentation rather than on price. I want the working, not the result — I need to be able to redo it with different numbers. I care…

cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by ruaidhri_o_shea 51k · 12 months ago
25 votes 5 answers21k views
Is a 30G needle the right choice for drawing tirzepatide at 6.67 mg/mL?

The case in front of me: a 30G needle · tirzepatide · 6.67 mg/mL. These are treated as interchangeable and I do not think they are. If both are acceptable I would…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

85 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

90 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
asked by gel_pack_warm 13k · 9 months ago
24 votes 5 answers46k views
Why is my second draw from the same vial reading a different volume?

I keep a written log of every draw with date, volume and syringe type. Something has gone wrong and I would like to know how badly before I decide what to do. Nothing…

insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by deamidation_watch 43k · 23 months ago
24 votes 3 answers23k views
Why does my 10 mg vial only yield about 9.2 mg of usable draws even with low-dead-space syringes?

I switched to fixed-needle U-100 insulin syringes after reading that dead space costs a fortune with luer fittings, and my yield improved a lot. But I still cannot…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
asked by mateo_iglesias 16k · 11 months ago
24 votes5 answers14k views
Is a 29G needle the right choice for drawing retatrutide at 5 mg/mL?

Numbers first: a 29G needle · retatrutide · 5 mg/mL. I have used one of these for a while and I am considering switching, which requires a reason. What I care about…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

85 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

90 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
asked by linnea_wahlberg 14k · 3 months ago
24 votes2 answers13k views
Is a 31G needle the right choice for drawing retatrutide at 20 mg/mL?

Numbers first: a 31G needle · retatrutide · 20 mg/mL. I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

85 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

90 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
asked by fill_volume 13k · 5 months ago
23 votes 5 answers18k views
What is the dead-space loss per draw with a 25G drawing needle at 3.33 mg/mL?

Concretely: a 25G drawing needle · 3.33 mg/mL. Please show the division. I want to check my own against yours. I would like the general form as well as the specific…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by priya_menon 11k · 23 months ago
23 votes5 answers7.2k views
Is a 18G drawing needle the right choice for drawing retatrutide at 5 mg/mL?

What I have: an 18G drawing needle · retatrutide · 5 mg/mL. I have used one of these for a while and I am considering switching, which requires a reason. What I care…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

85 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

90 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
asked by pk_curve 12k · 2 months ago
23 votes 3 answers4.6k views
What is the dead-space loss per draw with a 25G drawing needle at 8 mg/mL?

Concretely: a 25G drawing needle · 8 mg/mL. Please show the division. I want to check my own against yours. I would like the general form as well as the specific…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by eighty_six_hours 16k · 2 months ago
22 votes 5 answers17k views
Is a 27G needle the right choice for drawing cagrilintide at 4 mg/mL?

Stated plainly: a 27G needle · cagrilintide · 4 mg/mL. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can obtain…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

85 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

90 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
asked by Dr_Colm_Fitzhenry 85k · 10 months ago
22 votes0 answers8.8k views
What is the dead-space loss per draw with a 18G drawing needle at 1 mg/mL?

For reference: an 18G drawing needle · 1 mg/mL. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by RP_C18 85k · 3 months ago
22 votes 5 answers4.3k views
Is a 18G drawing needle the right choice for drawing survodutide at 2 mg/mL?

The specifics, since they change the answer: an 18G drawing needle · survodutide · 2 mg/mL. The comparison I want does not seem to exist anywhere in a form I can…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

85 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

90 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
asked by low_dead_space 42k · 3 months ago
21 votes 5 answers32k views
What is the dead-space loss per draw with a 30G needle at 2 mg/mL?

Setup, so nobody has to ask: a 30G needle · 2 mg/mL. I have worked this out and I would like someone to find the error, because I suspect there is one. My working so…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by second_lot 11k · 18 months ago
21 votes 5 answers16k views
Is a 18G drawing needle the right choice for drawing survodutide at 5 mg/mL?

For reference: an 18G drawing needle · survodutide · 5 mg/mL. I am trying to choose between two options that are usually discussed as though only one exists. I am not…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

85 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

90 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
asked by jo_vandeberg 19k · 22 months ago
21 votes5 answers12k views
What is the dead-space loss per draw with a 31G needle at 4 mg/mL?

Details up front: a 31G needle · 4 mg/mL. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary; the method…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by tare_and_weigh 18k · 8 months ago
21 votes5 answers10k views
What is the dead-space loss per draw with a 30G needle at 20 mg/mL?

Setup, so nobody has to ask: a 30G needle · 20 mg/mL. I have worked this out and I would like someone to find the error, because I suspect there is one. My working so…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by unit_math 13k · 2 months ago
20 votes 5 answers44k views
Is a 27G needle the right choice for drawing mazdutide at 6.67 mg/mL?

Stated plainly: a 27G needle · mazdutide · 6.67 mg/mL. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can obtain…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

85 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

90 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
asked by esther_vandeVelde 49k · 23 months ago