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storage

Page 4 of 27 · 646 questions tagged storage.

646 questions · sorted by votes · page 4 of 27

34 votes 5 answers51k views
How many freeze-thaw cycles will survodutide at 20 mg/mL tolerate?

Conditions: survodutide · 20 mg/mL. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already made one mistake here…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by Dr_Ilse_Vandenberg 78k · 2.0 years ago
34 votes 5 answers43k views
Is 25 °C an acceptable storage condition for lyophilised oral semaglutide?

The case in front of me: 25 °C · oral semaglutide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by gunnar_isaksen 16k · 18 months ago
34 votes5 answers40k views
Is there any published stability data for survodutide at 37 °C?

Conditions: survodutide · 37 °C. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one. Has anyone…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by forty_two_c 43k · 21 months ago
34 votes 5 answers36k views
Is a wine cooler good enough for storing reconstituted a GLP-1 receptor agonist?

Setup, so nobody has to ask: a wine cooler · a GLP-1 receptor agonist. I am trying to build something sustainable rather than something thorough that I will abandon.…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by wren_calloway 14k · 20 months ago
34 votes 5 answers35k views
What happens to ecnoglutide after twelve weeks at minus 80 °C in solution?

Conditions: ecnoglutide · twelve weeks · minus 80 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by teodora_ilic 15k · 14 months ago
34 votes5 answers35k views
Does deamidation dominate for ecnoglutide held at 40 °C?

The specifics, since they change the answer: deamidation · ecnoglutide · 40 °C. I would like the mechanism, because I want to be able to reason about the cases nobody…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by stopper_core 50k · 17 months ago
34 votes 5 answers33k views
Is a laboratory refrigerator good enough for storing reconstituted oral semaglutide?

Conditions: a laboratory refrigerator · oral semaglutide. The failure mode I am trying to avoid is making this decision emotionally. I have twelve months in view and…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by assay_blank 39k · 2.1 years ago
34 votes 3 answers25k views
What is the thermal exposure on a Shanghai to Japan lane in summer?

The case in front of me: Shanghai · Japan. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by esther_vandeVelde 49k · 2.3 years ago
34 votes0 answers21k views
Does a phase-change pack hold a tirzepatide shipment for forty-two days in transit?

For reference: tirzepatide · forty-two days. I would rather understand the derivation than memorise the outcome. Two people I asked gave two answers that differ by a…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by n_takahashi 36k · 13 months ago
34 votes0 answers19k views
Is there any published stability data for a GLP-1 receptor agonist at 2–8 °C?

What I have: a GLP-1 receptor agonist · 2–8 °C. I would rather be corrected now than propagate something wrong. I am specifically not interested in a testimonial; I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by kofi_mensah 12k · 16 months ago
33 votes 5 answers44k views
Does an insulated cool box plus a logger count as a defensible cold chain?

The vial was lyophilised at the time, which I understand may matter a great deal. I would like to set this up properly once, rather than adjust it repeatedly. My…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by Dr_Idris_Coulibaly 40k · 17 months ago
33 votes 5 answers44k views
Is there any published stability data for orforglipron at 40 °C?

What I am working with: orforglipron · 40 °C. This has the shape of a fact but I cannot find its origin. What I found instead were three secondary sources all citing…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by rukhsana_iqbal 14k · 17 months ago
33 votes 5 answers39k views
Does dimerisation dominate for a GLP-1 receptor agonist held at 2–8 °C?

What I am working with: dimerisation · a GLP-1 receptor agonist · 2–8 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by haze_check 17k · 17 months ago
33 votes 5 answers34k views
What is the thermal exposure on a Nantong to Canada lane in summer?

Stated plainly: Nantong · Canada. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline. I do not…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by tamsin_wray 13k · 12 months ago
33 votes5 answers32k views
Is a mini-fridge good enough for storing reconstituted cagrilintide?

Setup, so nobody has to ask: a mini-fridge · cagrilintide. I would like to set this up properly once, rather than adjust it repeatedly. My budget is real but not…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by aine_mulcahy 35k · 14 months ago
33 votes 5 answers25k views
What happens to orforglipron after eight weeks at 30 °C in solution?

Stated plainly: orforglipron · eight weeks · 30 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by Dr_Aoife_Brennan 50k · 20 months ago
33 votes 5 answers23k views
How many freeze-thaw cycles will mazdutide at 10 mg/mL tolerate?

What I have: mazdutide · 10 mg/mL. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a logger and…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by tamsin_wray 13k · 13 months ago
33 votes 5 answers23k views
What happens to liraglutide after ten weeks at 40 °C in solution?

The specifics, since they change the answer: liraglutide · ten weeks · 40 °C. I would like the mechanism, because I want to be able to reason about the cases nobody…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by siobhan_deasy 16k · 15 months ago
33 votes2 answers20k views
How many freeze-thaw cycles will cagrilintide at 6.67 mg/mL tolerate?

Details up front: cagrilintide · 6.67 mg/mL. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by jonas_ekstrom 18k · 15 months ago
33 votes2 answers16k views
Is room temperature an acceptable storage condition for lyophilised orforglipron?

Details up front: room temperature · orforglipron. I would rather be corrected now than propagate something wrong. I am specifically not interested in a testimonial;…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by cal_hennessy 14k · 15 months ago
33 votes 4 answers16k views
What happens to tirzepatide after ten weeks at minus 80 °C in solution?

For reference: tirzepatide · ten weeks · minus 80 °C. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by marcus_thorbjorn 16k · 12 months ago
33 votes 4 answers15k views
Does orforglipron adsorb measurably to the vial wall at 3.33 mg/mL?

Setup, so nobody has to ask: orforglipron · 3.33 mg/mL. I have worked this out and I would like someone to find the error, because I suspect there is one. My working…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by zeynep_arslan 20k · 20 months ago
33 votes 2 answers12k views
Is an insulated cool box good enough for storing reconstituted orforglipron?

Details up front: an insulated cool box · orforglipron. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by tabular_nums 47k · 18 months ago
32 votes 5 answers59k views
Is there any published stability data for mazdutide at minus 20 °C?

Details up front: mazdutide · minus 20 °C. I would rather be corrected now than propagate something wrong. I am specifically not interested in a testimonial; I am…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by vial_five 15k · 23 months ago