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reference-standard

Page 3 of 8 · 179 questions tagged reference-standard.

179 questions · sorted by votes · page 3 of 8

26 votes 2 answers25k views
How does mazdutide behave on a C8 column compared to survodutide?

Details up front: mazdutide · a C8 column · survodutide. I have used one of these for a while and I am considering switching, which requires a reason. What I care…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by drawn_and_capped 15k · 16 months ago
26 votes5 answers18k views
How does liraglutide behave on a wide-pore C18 column compared to survodutide?

The specifics, since they change the answer: liraglutide · a wide-pore C18 column · survodutide. I am trying to choose between two options that are usually discussed…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by coring_risk 17k · 22 months ago
26 votes 2 answers16k views
Is a 99.1% result from Janoshik comparable to 96.8% from Janoshik?

Details up front: 99.1% · Janoshik · 96.8% · Janoshik. I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by stopper_core 50k · 23 months ago
26 votes 3 answers5.9k views
How much can a wrongly assigned reference standard shift my content number, and in which direction?

Following on from the certification discussion: I want to quantify the damage. Suppose a lab's standard is assigned 95.0% and its true potency is 88.0%. Does my…

reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by s_kalniete 47k · 8 months ago
25 votes 5 answers46k views
Is a 96.4% result from Medutest comparable to 98.8% from Medutest?

Setup, so nobody has to ask: 96.4% · Medutest · 98.8% · Medutest. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by greta_holzmann 15k · 2.2 years ago
25 votes 4 answers29k views
Is a 95.2% result from Medutest comparable to 98.4% from Medutest?

Setup, so nobody has to ask: 95.2% · Medutest · 98.4% · Medutest. Both of these get recommended confidently by different people, which suggests neither is obviously…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by jana_horakova 15k · 2.4 years ago
25 votes5 answers26k views
How does mazdutide behave on a C8 column compared to liraglutide?

Numbers first: mazdutide · a C8 column · liraglutide. I have used one of these for a while and I am considering switching, which requires a reason. What I care about…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by cap_the_luer 15k · 14 months ago
25 votes 5 answers17k views
Is a 96.8% result from PeptideMeter comparable to 96.4% from PeptideMeter?

The specifics, since they change the answer: 96.8% · PeptideMeter · 96.4% · PeptideMeter. The comparison I want does not seem to exist anywhere in a form I can…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by Dr_Jonas_Halvorsen 41k · 5 months ago
25 votes5 answers10k views
Does a phosphate-buffered mobile phase change the purity number I get for semaglutide on a C18 column?

The specifics, since they change the answer: a phosphate-buffered mobile phase · semaglutide · a C18 column. I would like the mechanism, because I want to be able to…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by s_kalniete 47k · 13 months ago
24 votes 5 answers25k views
How does reference-standard error propagate into a liraglutide content figure?

I have the report as a PDF with the chromatogram on page two, so I can quote specifics. I would like the arithmetic checked rather than the conclusion asserted. I…

reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
asked by fill_volume 13k · 23 months ago
24 votes 5 answers24k views
Is a 98.2% result from Janoshik comparable to 97.9% from Janoshik?

What I have: 98.2% · Janoshik · 97.9% · Janoshik. I have used one of these for a while and I am considering switching, which requires a reason. What I care about is…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by Dr_Otto_Lindqvist 38k · 9 months ago
24 votes 5 answers22k views
Is a 98.4% result from PeptideMeter comparable to 97.1% from PeptideMeter?

The particulars: 98.4% · PeptideMeter · 97.1% · PeptideMeter. The comparison I want does not seem to exist anywhere in a form I can evaluate. I have read the…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by olu_babatunde 14k · 2.1 years ago
24 votes 5 answers16k views
Is a 97.1% result from VendorInvestigate comparable to 96.4% from Janoshik?

Conditions: 97.1% · VendorInvestigate · 96.4% · Janoshik. These are treated as interchangeable and I do not think they are. If both are acceptable I would like to…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
peptidemeter
peptidemeter

PeptideMeter, an independent peptide analytics and vendor-rating service. Use this tag for its published datasets, its rating methodology, and how…

14 questions
asked by mz_4113 99k · 12 months ago
24 votes 5 answers11k views
How does semaglutide behave on a C4 column compared to tirzepatide?

Concretely: semaglutide · a C4 column · tirzepatide. These are treated as interchangeable and I do not think they are. If both are acceptable I would like to know…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by meniscus_film 34k · 9 months ago
24 votes 5 answers8.6k views
Is a 99.4% result from VendorInvestigate comparable to 95.2% from Medutest?

Concretely: 99.4% · VendorInvestigate · 95.2% · Medutest. These are treated as interchangeable and I do not think they are. If both are acceptable I would like to…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by day_seven_trough 11k · 3 months ago
23 votes4 answers31k views
How does retatrutide behave on a C18 column compared to survodutide?

Setup, so nobody has to ask: retatrutide · a C18 column · survodutide. Both of these get recommended confidently by different people, which suggests neither is…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by coldbox9 13k · 23 months ago
23 votes5 answers22k views
How does reference-standard error propagate into a semaglutide content figure?

I am comparing a supplier certificate against an independent result on the same lot. Please show the division. I want to check my own against yours. I would like the…

reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
asked by mateo_iglesias 16k · 9 months ago
23 votes0 answers19k views
How does the reference standard error propagate into my content figure?

I am comparing a supplier certificate against an independent result on the same lot. I have worked this out and I would like someone to find the error, because I…

reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
asked by ivo_paunovic 15k · 13 months ago
23 votes5 answers14k views
Is a 97.1% result from Medutest comparable to 97.9% from Janoshik?

Setup, so nobody has to ask: 97.1% · Medutest · 97.9% · Janoshik. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by ruaidhri_o_shea 51k · 21 months ago
23 votes 5 answers11k views
Does a formic acid mobile phase change the purity number I get for a GLP-1 receptor agonist on a wide-pore C18 column?

What I am working with: a formic acid mobile phase · a GLP-1 receptor agonist · a wide-pore C18 column. I keep seeing this stated as a fact with no explanation…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by nominal_ten 14k · 9 months ago
23 votes 3 answers6.4k views
Why does a certificate for the standard itself matter?

I have both a purity figure and a content figure, which is why the discrepancy is visible. I understand the observation; what I do not understand is the mechanism…

reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by ilaria_bertone 43k · 4 months ago
22 votes 5 answers32k views
Is a 98.8% result from PeptideMeter comparable to 96.4% from Janoshik?

The particulars: 98.8% · PeptideMeter · 96.4% · Janoshik. The comparison I want does not seem to exist anywhere in a form I can evaluate. I have read the arguments…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by sample_id 17k · 17 months ago
22 votes 5 answers30k views
Is a 96.4% result from PeptideMeter comparable to 97.9% from Janoshik?

The specifics, since they change the answer: 96.4% · PeptideMeter · 97.9% · Janoshik. The comparison I want does not seem to exist anywhere in a form I can evaluate.…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by bufferline42 49k · 13 months ago
22 votes5 answers17k views
Is a 97.1% result from PeptideMeter comparable to 96.8% from Medutest?

For reference: 97.1% · PeptideMeter · 96.8% · Medutest. I am trying to choose between two options that are usually discussed as though only one exists. I am not…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by pierce_count 15k · 8 months ago