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reference-standard

Page 8 of 8 · 179 questions tagged reference-standard.

179 questions · sorted by votes · page 8 of 8

3 votes0 answers3.2k views
Is a 97.9% result from PeptideMeter comparable to 97.6% from Janoshik?

The specifics, since they change the answer: 97.9% · PeptideMeter · 97.6% · Janoshik. The comparison I want does not seem to exist anywhere in a form I can evaluate.…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by swab_stopper 16k · 14 months ago
3 votes5 answers2.4k views
Is a 97.1% result from Medutest comparable to 99.1% from Janoshik?

Setup, so nobody has to ask: 97.1% · Medutest · 99.1% · Janoshik. Both of these get recommended confidently by different people, which suggests neither is obviously…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by Dr_Ravi_Selvarajah 42k · 3 months ago
3 votes0 answers1.8k views
Does a TFA mobile phase change the purity number I get for dulaglutide on a C4 column?

Details up front: a TFA mobile phase · dulaglutide · a C4 column. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by threadlock7 14k · 8 months ago
2 votes 5 answers17k views
How do I know a laboratory is quantifying against a real standard?

The method section is present, which is unusual enough that I want to make use of it. The claim is plausible, which is exactly why I want to check it. I am able to…

reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by coldbox9 13k · 2.1 years ago
2 votes 3 answers15k views
How does dulaglutide behave on a C18 column compared to tirzepatide?

Setup, so nobody has to ask: dulaglutide · a C18 column · tirzepatide. I suspect the honest answer is that it depends, in which case I would like to know on what.…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by nominal_ten 14k · 2.2 years ago
2 votes5 answers9.6k views
How does survodutide behave on a C4 column compared to tirzepatide?

The case in front of me: survodutide · a C4 column · tirzepatide. These are treated as interchangeable and I do not think they are. If both are acceptable I would…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by halvard_ness 42k · 2.3 years ago
2 votes 5 answers6.6k views
Is a 95.2% result from VendorInvestigate comparable to 96.4% from Medutest?

Concretely: 95.2% · VendorInvestigate · 96.4% · Medutest. These are treated as interchangeable and I do not think they are. If both are acceptable I would like to…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by siobhan_deasy 16k · 10 months ago
2 votes5 answers5.5k views
Is a 95.2% result from VendorInvestigate comparable to 97.9% from Medutest?

Concretely: 95.2% · VendorInvestigate · 97.9% · Medutest. I would like the axes of comparison first and the recommendation second. I have tried the first option and…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
residual-solvent
residual-solvent

Solvents left behind by synthesis and purification - acetonitrile, TFA, DMF, DCM - their ICH limits, how they are measured by headspace GC, and…

14 questions
asked by Dr_Lena_Ostrowska 42k · 12 months ago
1 vote5 answers5.1k views
Is a 99.4% result from Medutest comparable to 96.8% from Medutest?

Setup, so nobody has to ask: 99.4% · Medutest · 96.8% · Medutest. Both of these get recommended confidently by different people, which suggests neither is obviously…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by orla_sheridan 14k · 7 months ago
1 vote3 answers3.7k views
Is a 95.2% result from Medutest comparable to 97.1% from Medutest?

Stated plainly: 95.2% · Medutest · 97.1% · Medutest. Both of these get recommended confidently by different people, which suggests neither is obviously right. My…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by nynke_dekker 18k · 4 months ago
1 vote0 answers266 views
Does a formic acid mobile phase change the purity number I get for mazdutide on a wide-pore C18 column?

Setup, so nobody has to ask: a formic acid mobile phase · mazdutide · a wide-pore C18 column. The empirical answer seems settled. The explanation does not. If the…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by mala_venkatesh 21k · 3 months ago