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What is the reported incidence of nausea on orforglipron in ATTAIN-1?

Asked 24 Sept 2024Modified 22 months agoViewed 8.1k times
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Setup, so nobody has to ask: nausea · orforglipron · ATTAIN-1.

I have read the primary source rather than the summary, which has left me with more questions.

I understand the headline. I do not understand the footnotes, and the footnotes look important.

What can I legitimately conclude from this figure?

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

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clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

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orforglipron

A non-peptide, orally bioavailable small-molecule GLP-1 receptor agonist studied in the ATTAIN programme. It is not a peptide, which changes…

219 questions
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askedsamir_bennani15k2724 Sept 2024
3Worth saying whether you are keeping fluids down, because that changes the answer. – tobias_maartens 2 months ago
2How severe, and does anything relieve it? Both matter for what people will say. – Dr_Fatima_Belkacem 7 days ago
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