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storage

Page 7 of 30 · 701 questions tagged storage.

701 questions · sorted by votes · page 7 of 30

29 votes 5 answers47k views
How long does semaglutide stay within specification at 4 °C once reconstituted?

The case in front of me: semaglutide · 4 °C. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by tare_weight 60k · 2.1 years ago
29 votes 5 answers40k views
Does a phase-change pack hold a retatrutide shipment for fourteen days in transit?

What I have: retatrutide · fourteen days. I have worked this out and I would like someone to find the error, because I suspect there is one. My working so far, for…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
asked by charge_state_3 16k · 15 months ago
29 votes 3 answers36k views
Is there any published stability data for oral semaglutide at minus 80 °C?

The particulars: oral semaglutide · minus 80 °C. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has tested that", I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
oral-glp1
oral-glp1

Oral routes for GLP-1 receptor agonism: peptide formulations rescued by absorption enhancers such as SNAC, and true small molecules that need no…

219 questions
asked by bac_or_bust 33k · 15 months ago
29 votes 3 answers33k views
Is freezing a reconstituted peptide solution ever acceptable, and what exactly does an ice crystal do to it?

Every label on an approved incretin product says do not freeze, and discard if frozen. I would like to know what that instruction is protecting against, because if I…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

57 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

313 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
asked by rosa_mendieta 8k · 21 months ago
29 votes 5 answers30k views
How many freeze-thaw cycles will orforglipron at 20 mg/mL tolerate?

Setup, so nobody has to ask: orforglipron · 20 mg/mL. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

57 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
orforglipron
orforglipron

A non-peptide, orally bioavailable small-molecule GLP-1 receptor agonist studied in the ATTAIN programme. It is not a peptide, which changes…

219 questions
asked by ahmed_zerouali 15k · 20 months ago
29 votes 5 answers29k views
Does a phase-change pack hold an ecnoglutide shipment for twenty-eight days in transit?

What I am working with: ecnoglutide · twenty-eight days. Please show the division. I want to check my own against yours. I would like the general form as well as the…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
ecnoglutide
ecnoglutide

A long-acting GLP-1 receptor agonist with a cAMP-biased signalling profile. A niche tag, mostly used for mechanism questions about biased agonism…

223 questions
asked by dana_wexler 11k · 14 months ago
29 votes 5 answers27k views
Why does racemisation accelerate at 4 °C rather than proceeding linearly?

Details up front: racemisation · 4 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I would…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
asked by threadlock7 19k · 11 months ago
29 votes 5 answers22k views
Does racemisation dominate for orforglipron held at 2–8 °C?

What I have: racemisation · orforglipron · 2–8 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
orforglipron
orforglipron

A non-peptide, orally bioavailable small-molecule GLP-1 receptor agonist studied in the ATTAIN programme. It is not a peptide, which changes…

219 questions
asked by Dr_Jonas_Halvorsen 28k · 18 months ago
29 votes 5 answers17k views
Is there any published stability data for survodutide at 2–8 °C?

Concretely: survodutide · 2–8 °C. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one. Has anyone…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
asked by Dr_Otto_Lindqvist 72k · 11 months ago
29 votes 5 answers15k views
Does a domestic warehouse leg genuinely shorten cold-chain exposure?

The vial was lyophilised at the time, which I understand may matter a great deal. I want to know whether there is evidence behind this or only repetition. I have…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
asked by halvard_ness 69k · 10 months ago
29 votes 5 answers14k views
How long does cagrilintide stay within specification at 25 °C once reconstituted?

What I have: cagrilintide · 25 °C. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a logger and…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
amylin
amylin

Amylin and its analogues, most prominently cagrilintide, as a satiety mechanism orthogonal to incretin signalling. Includes the pharmacology of…

237 questions
asked by carys_meredith 12k · 9 months ago
29 votes 1 answer7.9k views
Does a GLP-1 receptor agonist adsorb measurably to the vial wall at 2.5 mg/mL?

Details up front: a GLP-1 receptor agonist · 2.5 mg/mL. This should be a straightforward calculation and I keep getting two different answers. The numbers are…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

476 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
asked by swab_and_wait 13k · 13 months ago
28 votes 5 answers46k views
Is a domestic freezer good enough for storing reconstituted semaglutide?

What I am working with: a domestic freezer · semaglutide. I am at the decision point and I would rather think it through than improvise. I would rather spend money on…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by carys_meredith 12k · 22 months ago
28 votes4 answers40k views
What is the thermal exposure on a Zhuhai to Ireland lane in summer?

Conditions: Zhuhai · Ireland. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree, which is…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
asked by marta_okonkwo 190k · 2.2 years ago
28 votes 5 answers38k views
Is there any published stability data for a GLP-1 receptor agonist at minus 20 °C?

What I have: a GLP-1 receptor agonist · minus 20 °C. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
asked by assay_blank 45k · 2.3 years ago
28 votes 5 answers34k views
How long does cagrilintide stay within specification at minus 20 °C once reconstituted?

What I have: cagrilintide · minus 20 °C. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
amylin
amylin

Amylin and its analogues, most prominently cagrilintide, as a satiety mechanism orthogonal to incretin signalling. Includes the pharmacology of…

237 questions
asked by w_okoye 43k · 2.2 years ago
28 votes 3 answers30k views
How do I read a lyophilised cake? Intact puck versus collapsed versus meltback versus a thin film

I have accumulated enough vials from enough sources that the cakes now look wildly different from each other, and I have no framework for interpreting that. Examples…

vial-inspection
vial-inspection

What you can learn by looking: cake morphology, meniscus films, fibres versus stopper fragments versus true particulates, clarity after…

66 questions
lyophilisation
lyophilisation

Freeze-drying: primary and secondary drying, collapse temperature, the role of bulking agents and cryoprotectants such as mannitol and trehalose,…

17 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
asked by bea_forsberg 11k · 2.0 years ago
28 votes 5 answers30k views
How long can a reconstituted vial sit at room temperature before I should bin it?

The material is still sealed, so I have not committed to anything yet. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer…

shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
asked by mass_shift_18 9.7k · 20 months ago
28 votes 2 answers30k views
Is a wine cooler good enough for storing reconstituted mazdutide?

Setup, so nobody has to ask: a wine cooler · mazdutide. I am trying to build something sustainable rather than something thorough that I will abandon. I have already…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
mazdutide
mazdutide

A GLP-1 and glucagon receptor dual agonist developed primarily in China, with a distinct dose range and a fast-moving publication record.…

237 questions
asked by ravenna_pace 14k · 16 months ago
28 votes0 answers29k views
What is the thermal exposure on a Changsha to Singapore lane in summer?

The case in front of me: Changsha · Singapore. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
asked by bea_forsberg 11k · 17 months ago
28 votes 5 answers29k views
What is the thermal exposure on a Changsha to Poland lane in summer?

Conditions: Changsha · Poland. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree, which…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
asked by priya_menon 13k · 20 months ago
28 votes0 answers28k views
Is there any published stability data for liraglutide at 40 °C?

The specifics, since they change the answer: liraglutide · 40 °C. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
liraglutide
liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

235 questions
asked by j_wierzbicki 69k · 22 months ago
28 votes5 answers28k views
Why does deamidation accelerate at 4 °C rather than proceeding linearly?

The specifics, since they change the answer: deamidation · 4 °C. I would like the mechanism, because I want to be able to reason about the cases nobody has written…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
asked by w_okoye 43k · 16 months ago
28 votes5 answers28k views
Does a mini-fridge plus a logger count as a defensible cold chain?

I have continuous temperature data for the period in question, which is unusual and I would like to use it. I would rather over-plan the first cycle and simplify…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
asked by jana_horakova 10k · 2.0 years ago