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shelf-life

Page 12 of 13 · 301 questions tagged shelf-life.

301 questions · sorted by votes · page 12 of 13

5 votes 5 answers15k views
Is 25 °C an acceptable storage condition for lyophilised liraglutide?

The case in front of me: 25 °C · liraglutide. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one.…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by pip_okonjo 11k · 2.0 years ago
5 votes 5 answers11k views
Is a GLP-1 receptor agonist at 10 mg/mL stable enough for two weeks of multi-withdrawal use?

Numbers first: a GLP-1 receptor agonist · 10 mg/mL · two weeks. I am asking for verification rather than opinion, ideally with something I can read myself. It is…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by rania_haddad 17k · 12 months ago
5 votes 5 answers5.3k views
What is the case for and against bacteriostatic water over four weeks of withdrawals?

The case in front of me: bacteriostatic water · four weeks. I would like the axes of comparison first and the recommendation second. I have tried the first option and…

bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
sterility
sterility

Sterility as a test result rather than an adjective. Covers what a sterility test actually measures, why "sterile filtered" on a document is close…

122 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by cake_collapsed 13k · 3 months ago
5 votes 5 answers5.1k views
How long does a GLP-1 receptor agonist stay within specification at 30 °C once reconstituted?

Numbers first: a GLP-1 receptor agonist · 30 °C. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked.…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by mateo_iglesias 16k · 3 months ago
5 votes5 answers4.9k views
Is minus 80 °C an acceptable storage condition for lyophilised semaglutide?

For reference: minus 80 °C · semaglutide. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has tested that", I would…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by klara_novotna 16k · 12 months ago
5 votes0 answers4.4k views
How long does retatrutide stay within specification at 30 °C once reconstituted?

Stated plainly: retatrutide · 30 °C. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the theory. What I have…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by loss_on_drying 47k · 2.1 years ago
5 votes5 answers3.3k views
How is a beyond-use date set for a compounded multi-dose vial?

Costs, fees and monitoring all included, I am trying to compare like with like. I can find plenty of assertions about this and almost no reasoning, which is usually a…

compounding
compounding

Compounded preparations: what a 503A and a 503B facility may legally prepare and when, base versus salt forms, beyond-use dating under USP…

61 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
asked by meniscus_film 34k · 8 months ago
5 votes0 answers1.7k views
What happens to a GLP-1 receptor agonist after sixteen weeks at minus 80 °C in solution?

Numbers first: a GLP-1 receptor agonist · sixteen weeks · minus 80 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by claudia_ferrante 46k · 2 months ago
4 votes 5 answers12k views
Is semaglutide at 2 mg/mL stable enough for three weeks of multi-withdrawal use?

Concretely: semaglutide · 2 mg/mL · three weeks. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by felix_araya 17k · 10 months ago
4 votes 5 answers9.3k views
What happens to retatrutide after two weeks at minus 20 °C in solution?

Stated plainly: retatrutide · two weeks · minus 20 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by claudia_ferrante 46k · 8 months ago
4 votes 5 answers8.7k views
How long does mazdutide stay within specification at 2–8 °C once reconstituted?

Numbers first: mazdutide · 2–8 °C. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a logger and…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by lyoph_cake 95k · 6 months ago
4 votes 5 answers5.8k views
Is 30 °C an acceptable storage condition for lyophilised semaglutide?

For reference: 30 °C · semaglutide. Somebody stated this to me confidently and I would like to check it before repeating it. I would accept a well-reasoned negative…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by swab_and_wait 15k · 2 months ago
4 votes 5 answers5.1k views
How long does mazdutide stay within specification at 40 °C once reconstituted?

What I have: mazdutide · 40 °C. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked. Assume no…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by vial_five 15k · 2 months ago
4 votes5 answers4.5k views
How long does mazdutide stay within specification at room temperature once reconstituted?

What I have: mazdutide · room temperature. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by triple_agonist_q 37k · 5 months ago
4 votes0 answers4.1k views
What happens to cagrilintide after six weeks at 2–8 °C in solution?

Numbers first: cagrilintide · six weeks · 2–8 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by cap_the_luer 15k · 19 months ago
4 votes 1 answer1.3k views
What happens to mazdutide after six weeks at 30 °C in solution?

Details up front: mazdutide · six weeks · 30 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by ines_delacruz 16k · 3 months ago
3 votes 5 answers9.2k views
What happens to cagrilintide after sixteen weeks at 2–8 °C in solution?

Numbers first: cagrilintide · sixteen weeks · 2–8 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by otto_brenner 19k · 13 months ago
3 votes 5 answers5k views
Is 30 °C an acceptable storage condition for lyophilised ecnoglutide?

The specifics, since they change the answer: 30 °C · ecnoglutide. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by lane_transit 42k · 33 days ago
3 votes 5 answers4.7k views
Is liraglutide at 10 mg/mL stable enough for four weeks of multi-withdrawal use?

The specifics, since they change the answer: liraglutide · 10 mg/mL · four weeks. Somebody stated this to me confidently and I would like to check it before repeating…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by gel_pack_warm 13k · 9 months ago
3 votes 5 answers2.7k views
How long does orforglipron stay within specification at 2–8 °C once reconstituted?

Stated plainly: orforglipron · 2–8 °C. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am comfortable with the…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by Dr_Lena_Ostrowska 42k · 34 days ago
3 votes 2 answers1.9k views
Is ecnoglutide at 20 mg/mL stable enough for ten weeks of multi-withdrawal use?

The case in front of me: ecnoglutide · 20 mg/mL · ten weeks. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by fresh_bac 13k · 2 months ago
3 votes0 answers1.6k views
What happens to cagrilintide after sixteen weeks at 37 °C in solution?

Details up front: cagrilintide · sixteen weeks · 37 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by g_paskevicius 44k · 11 months ago
2 votes 3 answers14k views
What happens to ecnoglutide after twelve weeks at 2–8 °C in solution?

Concretely: ecnoglutide · twelve weeks · 2–8 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by yuki_morishita 19k · 23 months ago
2 votes 5 answers12k views
What happens to ecnoglutide after twelve weeks at 4 °C in solution?

The case in front of me: ecnoglutide · twelve weeks · 4 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by harriet_lonsdale 14k · 13 months ago