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Is 30 °C an acceptable storage condition for lyophilised dulaglutide?

Asked 19 Dec 2025Modified 4 months agoViewed 2k times
8

Numbers first: 30 °C · dulaglutide.

I would rather be corrected now than propagate something wrong.

I am specifically not interested in a testimonial; I am interested in a measurement.

How well supported is this claim?

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askedtare_weight60k14819 Dec 2025
3Is the material lyophilised or already in solution? Completely different answer. – gunnar_isaksen 1 days ago
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1 Answer

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30 °C is above the refrigerated band, and how far above is the whole answer. 30 °C is 25 kelvin above the 5 °C middle of a 2–8 °C refrigerator. The ten-degree rule of thumb — degradation rate roughly doubling per 10 K — makes that about 5.7 times the refrigerated rate, which is an order-of-magnitude statement and not a shelf life. Lyophilised material tolerates this far better than solution does, which is why it is shipped that way, but "tolerates" is a statement about weeks and the vial is being asked about months. Log the excursion rather than guess at it. Nothing here is medical advice, and research-use-only material is not approved for human use.

The honest answer is that ordinary refrigeration handles almost every case people ask about.

Keep vials in their original carton or in an opaque box. Light exposure matters for tryptophan-containing sequences and for anything with a chromophore, and a closed box is free.

Degradation pathway by condition

PathwayDominant whenDetected by
DeamidationSolution, neutral to alkaline pHRP-HPLC, +1 Da on MS
OxidationLight, trace metals, peroxidesRP-HPLC, +16 Da on MS
HydrolysisSolution, extremes of pHRP-HPLC, fragment masses
AggregationAgitation, interfaces, high concentrationSEC, visual haze; often invisible on RP-HPLC
Freeze-concentration damageFreeze-thaw of buffered solutionSEC, loss of recovered content

Store with the desiccant sachet if one was supplied, inside the secondary container rather than loose in a drawer. Residual moisture is the dominant variable in solid-state stability.

Two-to-eight-degree refrigeration and minus-twenty freezing are the standard storage conditions for lyophilised peptides in supplier documentation across the market.

Dry, cold, dark, still. Four words and you have the answer.

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answeredlaminar_bench69k572 Apr 2026
Aliquoting before the first freeze is the advice I wish I had read two years ago. – Dr_Elias_Weiss 3 months ago
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Ask PeptideStack is a static archive. Posting is closed, but the norms are worth stating: answer the question that was asked, show your working, cite the trial or the certificate, and say plainly where the evidence runs out.

Not medical advice. Research-use-only compounds are not approved for human use.