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shelf-life

Page 10 of 13 · 301 questions tagged shelf-life.

301 questions · sorted by votes · page 10 of 13

12 votes 3 answers9.2k views
What is the case for and against sterile water for injection over ten weeks of withdrawals?

The particulars: sterile water for injection · ten weeks. The comparison I want does not seem to exist anywhere in a form I can evaluate. I have read the arguments…

bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
sterility
sterility

Sterility as a test result rather than an adjective. Covers what a sterility test actually measures, why "sterile filtered" on a document is close…

122 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by swab_stopper 16k · 7 months ago
12 votes 5 answers7.7k views
Is mazdutide at 6.67 mg/mL stable enough for two weeks of multi-withdrawal use?

Numbers first: mazdutide · 6.67 mg/mL · two weeks. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by rania_haddad 17k · 2 months ago
12 votes2 answers7.3k views
Is oral semaglutide at 1 mg/mL stable enough for four weeks of multi-withdrawal use?

The particulars: oral semaglutide · 1 mg/mL · four weeks. Somebody stated this to me confidently and I would like to check it before repeating it. I would accept a…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by swirl_dont_shake 19k · 5 months ago
12 votes 2 answers6k views
How long does ecnoglutide stay within specification at 25 °C once reconstituted?

The case in front of me: ecnoglutide · 25 °C. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by syringe_ninety 15k · 11 months ago
12 votes3 answers1.6k views
Is retatrutide at 20 mg/mL stable enough for sixteen weeks of multi-withdrawal use?

Setup, so nobody has to ask: retatrutide · 20 mg/mL · sixteen weeks. This is asserted often enough that I assumed it was established, and then I went looking for the…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by harriet_lonsdale 14k · 14 days ago
11 votes 5 answers32k views
What happens to semaglutide after twelve weeks at room temperature in solution?

Concretely: semaglutide · twelve weeks · room temperature. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by sunniva_dahl 11k · 2.3 years ago
11 votes 3 answers24k views
How long does orforglipron stay within specification at 25 °C once reconstituted?

What I am working with: orforglipron · 25 °C. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am comfortable…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by Dr_Marek_Zielinski 39k · 21 months ago
11 votes 5 answers15k views
What happens to tirzepatide after ten weeks at 2–8 °C in solution?

The specifics, since they change the answer: tirzepatide · ten weeks · 2–8 °C. I would like the mechanism, because I want to be able to reason about the cases nobody…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by mg_per_ml 12k · 11 months ago
11 votes 5 answers12k views
What happens to orforglipron after eight weeks at 25 °C in solution?

What I am working with: orforglipron · eight weeks · 25 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by rae_oyelowo 21k · 5 months ago
11 votes0 answers10k views
Is minus 20 °C an acceptable storage condition for lyophilised survodutide?

The specifics, since they change the answer: minus 20 °C · survodutide. Somebody stated this to me confidently and I would like to check it before repeating it. I…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by tare_weight 47k · 15 months ago
11 votes5 answers10k views
What happens to a GLP-1 receptor agonist after sixteen weeks at 30 °C in solution?

Details up front: a GLP-1 receptor agonist · sixteen weeks · 30 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by tenth_of_a_unit 40k · 17 months ago
11 votes0 answers6.5k views
Is minus 20 °C an acceptable storage condition for lyophilised liraglutide?

Conditions: minus 20 °C · liraglutide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and monographs…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by ivo_paunovic 15k · 12 months ago
11 votes 1 answer3k views
What happens to oral semaglutide after three weeks at 37 °C in solution?

The specifics, since they change the answer: oral semaglutide · three weeks · 37 °C. I understand the observation; what I do not understand is the mechanism behind…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by seven_day_half 16k · 33 days ago
11 votes5 answers2.8k views
What happens to mazdutide after sixteen weeks at minus 80 °C in solution?

Numbers first: mazdutide · sixteen weeks · minus 80 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by elke_brunner 14k · 2 months ago
10 votes5 answers22k views
How long does ecnoglutide stay within specification at 40 °C once reconstituted?

The case in front of me: ecnoglutide · 40 °C. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by pascal_thibault 13k · 17 months ago
10 votes 5 answers15k views
Is 37 °C an acceptable storage condition for lyophilised mazdutide?

Stated plainly: 37 °C · mazdutide. This is asserted often enough that I assumed it was established, and then I went looking for the source. I have searched the…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by lucia_marchetti 18k · 20 months ago
10 votes 5 answers14k views
What happens to retatrutide after eight weeks at 4 °C in solution?

What I am working with: retatrutide · eight weeks · 4 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious.…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by unit_math 13k · 19 months ago
10 votes3 answers12k views
Is cagrilintide at 6.67 mg/mL stable enough for eight weeks of multi-withdrawal use?

Details up front: cagrilintide · 6.67 mg/mL · eight weeks. I would rather be corrected now than propagate something wrong. I am specifically not interested in a…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by zeynep_arslan 20k · 13 months ago
10 votes 4 answers10k views
Is retatrutide at 2 mg/mL stable enough for six weeks of multi-withdrawal use?

Setup, so nobody has to ask: retatrutide · 2 mg/mL · six weeks. This has the shape of a fact but I cannot find its origin. What I found instead were three secondary…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by bufferline42 49k · 5 months ago
10 votes 3 answers9.7k views
What happens to liraglutide after three weeks at minus 80 °C in solution?

For reference: liraglutide · three weeks · minus 80 °C. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by Dr_Elias_Weiss 46k · 7 months ago
10 votes5 answers9.2k views
How long does tirzepatide stay within specification at minus 20 °C once reconstituted?

The specifics, since they change the answer: tirzepatide · minus 20 °C. I have read the obvious sources and they disagree with each other, so I would rather ask…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by tare_and_weigh 18k · 8 months ago
10 votes 5 answers3.8k views
What happens to ecnoglutide after twelve weeks at room temperature in solution?

Conditions: ecnoglutide · twelve weeks · room temperature. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by lucia_marchetti 18k · 2 months ago
9 votes 5 answers25k views
How long does liraglutide stay within specification at 37 °C once reconstituted?

The particulars: liraglutide · 37 °C. I have read the obvious sources and they disagree with each other, so I would rather ask people who have actually done this. I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by tobias_reint 19k · 20 months ago
9 votes 5 answers11k views
What happens to ecnoglutide after four weeks at 2–8 °C in solution?

The case in front of me: ecnoglutide · four weeks · 2–8 °C. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by rosa_mendieta 13k · 13 months ago