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coa

Page 6 of 32 · 749 questions tagged coa.

749 questions · sorted by votes · page 6 of 32

30 votes 5 answers35k views
How do I reconcile 96.8% from Medutest with 98.8% from the supplier?

Setup, so nobody has to ask: 96.8% · Medutest · 98.8%. This is not behaving the way I expected and I want to understand the discrepancy before I act on it. I have…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by Dr_Tomas_Kral 37k · 12 months ago
30 votes 4 answers32k views
What would you ask GL Biochem (Shanghai) before a first order that they cannot fake?

The lane and the lead time matter as much as the material for what I am doing. I want a method I can write down and repeat, not a rule of thumb. I would rather…

vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by kirsi_lahtinen 45k · 2.2 years ago
30 votes 5 answers29k views
What does a residual-solvent screen add for cagrilintide that a purity figure does not?

What I am working with: a residual-solvent screen · cagrilintide. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I…

content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by threadlock7 14k · 9 months ago
30 votes 5 answers29k views
What does 96.4% purity on a C18 column actually tell me about an ecnoglutide vial?

Stated plainly: 96.4% · a C18 column · ecnoglutide. I have read the primary source rather than the summary, which has left me with more questions. I understand the…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by plunger_stop 18k · 13 months ago
30 votes5 answers24k views
How do I reconcile 97.6% from PeptideMeter with 95.2% from the supplier?

For reference: 97.6% · PeptideMeter · 95.2%. An unexpected observation, and I would like a differential rather than reassurance. The conditions were within what I…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by mira_sundqvist 19k · 23 months ago
30 votes 5 answers19k views
How do I reconcile 99.1% from Medutest with 96.4% from the supplier?

Stated plainly: 99.1% · Medutest · 96.4%. This is not behaving the way I expected and I want to understand the discrepancy before I act on it. I have photographed the…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by pip_okonjo 11k · 15 months ago
30 votes5 answers15k views
What does 99.4% purity on a C8 column actually tell me about a liraglutide vial?

Numbers first: 99.4% · a C8 column · liraglutide. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by pk_curve 12k · 12 months ago
30 votes0 answers14k views
Has anyone independently verified a QYB ecnoglutide batch COA?

The specifics, since they change the answer: QYB · ecnoglutide. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has…

vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by kofi_mensah 12k · 19 months ago
30 votes5 answers11k views
What should I make of an ecnoglutide certificate that has no method section?

The case in front of me: ecnoglutide · method section. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a…

coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by petra_hovland 42k · 11 months ago
30 votes0 answers9.1k views
What does 98.8% purity on a C8 column actually tell me about a tirzepatide vial?

Numbers first: 98.8% · a C8 column · tirzepatide. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by j_wierzbicki 45k · 14 months ago
29 votes 5 answers58k views
How do I reconcile 99.4% from VendorInvestigate with 98.4% from the supplier?

Conditions: 99.4% · VendorInvestigate · 98.4%. I have two candidate explanations and no way to distinguish them. The same procedure has worked without incident…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by two_two_micron 15k · 2.0 years ago
29 votes 5 answers53k views
What does a 96.8% purity with a date of analysis attached let me conclude?

Conditions: 96.8% · date of analysis. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result,…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by triple_agonist_q 37k · 2.1 years ago
29 votes 5 answers46k views
How do I reconcile 99.4% from Medutest with 96.4% from the supplier?

Stated plainly: 99.4% · Medutest · 96.4%. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not discarded anything…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by zainab_mustafa 16k · 19 months ago
29 votes4 answers41k views
What should I make of an ecnoglutide certificate that has no date of analysis?

Concretely: ecnoglutide · date of analysis. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…

coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by grainne_ahearn 13k · 21 months ago
29 votes 5 answers38k views
What does a 503A pharmacy need to prepare dulaglutide lawfully?

I would like to understand the process rather than be told to try harder. I have read the primary source rather than the summary, which has left me with more…

pharmacy-503a
pharmacy-503a

Section 503A traditional compounding pharmacies specifically: patient-specific prescriptions, accreditation such as PCAB and ACHC, USP 797…

17 questions
compounding
compounding

Compounded preparations: what a 503A and a 503B facility may legally prepare and when, base versus salt forms, beyond-use dating under USP…

61 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by eoin_mcgarry 16k · 17 months ago
29 votes 4 answers33k views
What would you ask Hunan Aslsen Technology before a first order that they cannot fake?

I am comparing three suppliers on documentation rather than on price. Everything I have found on this is either a forum aside or a product page, neither of which I…

vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by n_takahashi 36k · 2.2 years ago
29 votes 5 answers32k views
What does a chromatogram on an SSA report change about how I read it?

The case in front of me: chromatogram · SSA. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single…

coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by sunniva_dahl 11k · 12 months ago
29 votes0 answers32k views
How does QST compare to Shanghai Wibson Biotechnology on documentation quality?

Conditions: QST · Shanghai Wibson Biotechnology. I would like the axes of comparison first and the recommendation second. I have tried the first option and it works;…

vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by ivo_paunovic 15k · 21 months ago
29 votes2 answers31k views
How does KP compare to Shanghai ERP Biotechnology on documentation quality?

Details up front: KP · Shanghai ERP Biotechnology. I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a…

vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by low_dead_space 42k · 17 months ago
29 votes5 answers31k views
How do I reconcile 99.1% from VendorInvestigate with 98.4% from the supplier?

The case in front of me: 99.1% · VendorInvestigate · 98.4%. I have two candidate explanations and no way to distinguish them. The same procedure has worked without…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by jo_vandeberg 19k · 14 months ago
29 votes 5 answers28k views
How does Homopeptide compare to Zhuhai Kerui Biotechnology on documentation quality?

Conditions: Homopeptide · Zhuhai Kerui Biotechnology. I would like the axes of comparison first and the recommendation second. I have tried the first option and it…

vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by area_percent 13k · 21 months ago
29 votes 5 answers28k views
How do I reconcile 97.6% from Janoshik with 98.8% from the supplier?

Numbers first: 97.6% · Janoshik · 98.8%. Before I write this off, I want to check whether it is a known failure mode. I have the lot number, the certificate and the…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by cap_the_luer 15k · 18 months ago
29 votes3 answers26k views
What would you ask Shanghai Wibson Biotechnology before a first order that they cannot fake?

I have certificates from two lots and an independent result on one of them. I can find plenty of assertions about this and almost no reasoning, which is usually a…

vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by pieter_maas 22k · 10 months ago
29 votes 5 answers22k views
What should I make of a retatrutide certificate that has no sampling plan?

What I am working with: retatrutide · sampling plan. I have read the primary source rather than the summary, which has left me with more questions. I understand the…

coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by lucia_marchetti 18k · 19 months ago