What is the reported incidence of nausea on mazdutide in ATTAIN-1?

Asked 24 Sept 2024Modified 22 months agoViewed 8.1k times

Setup, so nobody has to ask: nausea · mazdutide · ATTAIN-1.

I have read the primary source rather than the summary, which has left me with more questions.

I understand the headline. I do not understand the footnotes, and the footnotes look important.

What can I legitimately conclude from this figure?

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

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Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

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The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

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askedsamir_bennani13k1824 Sept 2024

5I would add a sentence about sterility here, since it is the thing people skip. – v_ramaswamy 6 months ago

4The placebo-arm figure is the part everyone omits. – kwn_analytical 5 months ago

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