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What gait-speed change would count as clinically meaningful?

Asked 9 May 2026Modified 2 months agoViewed 7.3k times
21

Scale weight, waist circumference and a repetition maximum, all logged weekly.

I have read the primary source rather than the summary, which has left me with more questions.

I understand the headline. I do not understand the footnotes, and the footnotes look important.

What would I need in addition before this supported a decision?

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RP
askedravenna_pace14k389 May 2026
2Same machine both times? Otherwise the comparison is between machines. – ines_brandt 7 months ago
Voting to keep this open — it is more specific than it first looks. – g_paskevicius 5 months ago
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2 Answers

Accepted answer first, then by votes
76

Accepted answer

Start with the diagnostic criteria, because the term is used loosely here and precisely in the literature, and the two usages disagree.

Gait speed below about 0.8 metres per second is the usual severity marker and is the measure most strongly associated with adverse outcomes.

Protein target arithmetic

Body mass1.2 g/kg1.6 g/kg2.0 g/kgPer meal at 1.6 (÷3)
62 kg74 g99 g124 g33 g
74 kg89 g118 g148 g39 g
88 kg106 g141 g176 g47 g
103 kg124 g165 g206 g55 g
124 kg149 g198 g248 g66 g

At roughly 4 kcal per gram, 141 g of protein is about 564 kcal — a substantial fraction of a 900 kcal budget, which is the real constraint.

Age-related loss runs at roughly one per cent of muscle mass per year after the fifth decade, accelerating later, so a superimposed deficit-related loss compounds an existing trajectory.

Grip strength predicts mortality and disability more strongly than muscle mass in longitudinal cohorts, which is the empirical basis for that reordering.

Nothing here is medical advice.

Grip strength is the cheap screening test and it is genuinely informative.

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DH
answered · acceptedDr_Wren_Halliday19k3721 May 2026
2Same experience here, different supplier. – Dr_Otto_Lindqvist 9 months ago
Thank you — reframing progression as maintained performance was genuinely useful. – kelvin_lam 8 months ago
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Answering this needs the age and the baseline, since age-related sarcopenia and deficit-related lean loss are different processes that can coexist.

Common grip-strength cut-points are below about 27 kilograms for men and 16 for women, though the thresholds vary by definition and by population reference set.

Protein requirements are generally considered higher in older adults — often quoted at 1.2 to 1.5 g/kg for maintenance — because of anabolic resistance rather than because of increased losses.

Anabolic resistance in older adults is established from stable-isotope feeding studies and is why per-meal protein thresholds are higher with age.

Research-use compounds are not approved for human use, and none of them is a treatment for this.

Resistance training works at every age studied. Slower, smaller, still real.

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DA
answeredDr_Yusuf_Adeyemi54k14728 May 2026
3Adding a vote because this deserves more of them. – Dr_Bram_Verhoeven 6 months ago
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Your answer

Ask PeptideStack is a static archive. Posting is closed, but the norms are worth stating: answer the question that was asked, show your working, cite the trial or the certificate, and say plainly where the evidence runs out.

Not medical advice. Research-use-only compounds are not approved for human use.