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Do the trial populations say anything usable about sarcopenia risk?

Asked 30 Dec 2024Modified 15 months agoViewed 15k times
14

The trend is what I care about; individual weeks are obviously noise.

I would like to know whether this claim survives contact with evidence.

If the answer is "nobody has tested that", I would like that stated so I can stop looking.

How well supported is this claim?

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askedDr_Rosalind_Achebe69k14730 Dec 2024

5 Answers

Accepted answer first, then by votes
120

Accepted answer

The short version: strength first, mass second, physical performance to grade severity. That ordering is deliberate and recent.

Appendicular skeletal muscle mass index below roughly 7.0 kg/m² in men and 5.5 kg/m² in women is the usual confirmatory threshold on DXA.

What each body-composition method measures

MethodMeasuresSensitive toLeast significant change
DEXAThree-compartment by attenuationHydration, positioning~2–3 % regional lean
BIA (consumer)Impedance, modelledHydration, food, temperatureNot usable at this timescale
Air displacementTwo-compartment by densityLung volume, hair, clothing~1–2 % fat mass
Tape and scaleCircumference, massTechniqueSurprisingly usable as a trend

Age-related loss runs at roughly one per cent of muscle mass per year after the fifth decade, accelerating later, so a superimposed deficit-related loss compounds an existing trajectory.

The current operational definition comes from the revised European consensus, which moved strength ahead of mass as the primary criterion.

Higher protein per meal with age, because of anabolic resistance.

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answered · acceptedDr_Ingrid_Baumgartner73k582 Feb 2025
Thank you — reframing progression as maintained performance was genuinely useful. – anouk_desmet 5 months ago
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49

The condition is defined against population reference values, so absolute numbers matter more than personal trends here.

The European working group definition uses low grip strength or low chair-stand performance as the entry criterion, confirms with low appendicular skeletal muscle mass adjusted for height, and grades severity by gait speed or a short physical performance battery.

Concretely, resistance training remains effective into the ninth decade; the response is slower and smaller than in younger adults but it is not absent, which is the single most useful fact in this tag.

The caveat is that this is a clinical diagnosis and self-diagnosis from a home scale is not possible; bioimpedance in particular is unreliable at these thresholds.

Resistance training works at every age studied. Slower, smaller, still real.

edited 19 Feb 2025 by a_lindgren — added a caveat about sampling

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AL
answereda_lindgren58k24822 Jan 2025
Same experience here, different supplier. – marta_okonkwo 8 months ago
8This should be linked from the help pages. – lane_transit 6 months ago
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34

Answer first: sarcopenia is defined by low muscle strength with low muscle quantity, and function rather than mass is the primary criterion in the current definitions.

Gait speed below about 0.8 metres per second is the usual severity marker and is the measure most strongly associated with adverse outcomes.

To be exact about it, common grip-strength cut-points are below about 27 kilograms for men and 16 for women, though the thresholds vary by definition and by population reference set.

Anabolic resistance in older adults is established from stable-isotope feeding studies and is why per-meal protein thresholds are higher with age.

Strength first, mass second, performance for severity. That is the definition.

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answeredDr_Wren_Halliday19k3711 Jan 2025
28

The honest answer is that rapid weight loss in an older adult without resistance training is a genuine risk factor, and that the mitigation is entirely unglamorous.

Protein requirements are generally considered higher in older adults — often quoted at 1.2 to 1.5 g/kg for maintenance — because of anabolic resistance rather than because of increased losses.

Nothing here is medical advice.

Grip strength is the cheap screening test and it is genuinely informative.

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answeredDr_Yusuf_Adeyemi54k14731 Dec 2024
26

Grip strength is the standard screening measure because it is cheap, repeatable and predicts outcomes better than mass does.

Sarcopenic obesity is the combination that matters in this population: adequate or high total mass with low muscle mass, which no scale detects and which a body-mass index actively conceals.

Sarcopenic obesity is invisible on a scale. Measure or you will not see it.

edited 21 Apr 2025 by forty_two_c — added the placebo-arm figures

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answeredforty_two_c66k5819 Apr 2025
8Thank you — this is the answer I was looking for. – tandem_gradient 4 months ago
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Your answer

Ask PeptideStack is a static archive. Posting is closed, but the norms are worth stating: answer the question that was asked, show your working, cite the trial or the certificate, and say plainly where the evidence runs out.

Not medical advice. Research-use-only compounds are not approved for human use.