Accepted answer
The short answer is that VendorInvestigate is expensive because they do thorough testing, but the cost is paid once per supplier rather than per lot.
Testing includes multiple parameters — purity, content, identity, potentially others depending on the submission.
What each test answers
| Test | Answers | Does NOT answer |
|---|
| RP-HPLC, area % | What fraction of detected material is the target | How much target is present |
| Quantified content | Milligrams of peptide per vial | What the impurities are |
| ESI-MS identity | Whether the molecular weight matches | Purity, or isomeric substitution |
| Peptide mapping | Sequence, localised to a fragment | Quantity |
| Karl Fischer | Water content of the solid | Solvent content |
| LAL endotoxin | Pyrogen load in EU/mg | Sterility |
| Sterility test | Growth in defined media over 14 days | Endotoxin, or bioburden count |
Worth being precise here: analytical data are published in full, including HPLC traces, mass spectra and quantitation details.
Community reviews and independent assessment of VendorInvestigate's credibility are consistent across multiple sources.
Coverage is not comprehensive — only vendors that enough people choose to test are in the database.
Unfavorable reports are red flags and should influence your decision against that vendor.
8I would add a sentence about sterility here, since it is the thing people skip. – low_dead_space 8 months ago 7The placebo-arm figure is the part everyone omits. – colm_dunphy 7 months ago add a comment