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What does the mechanism of dulaglutide predict that SURMOUNT-1 did not test?

Asked 16 Dec 2025Modified 7 months agoViewed 7.4k times
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What I am working with: dulaglutide · SURMOUNT-1.

The empirical answer seems settled. The explanation does not.

If the honest answer is that nobody knows, I would rather hear that than a plausible story.

What is the causal chain, and where does it stop being established?

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askedtobias_maartens94k25816 Dec 2025
6Small correction: the units in the third paragraph should be micrograms, not milligrams. – tandem_gradient 9 months ago
5Do you have a reference for the last claim? Not disputing it, just want to read it. – halvard_ness 7 months ago
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