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Does a TFA mobile phase change the purity number I get for dulaglutide on a C4 column?

Asked 3 Dec 2025Modified 8 months agoViewed 1.8k times
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Details up front: a TFA mobile phase · dulaglutide · a C4 column.

I suspect the usual explanation for this is wrong, or at least incomplete.

I am aware this may have a boring answer. I would still like the boring answer stated clearly.

Can someone derive this rather than assert it?

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askedthreadlock714k263 Dec 2025
5Good answer, but the confidence interval in the cited trial is wider than implied. – lyoph_cake 6 months ago
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