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storage

Page 23 of 30 · 701 questions tagged storage.

701 questions · sorted by votes · page 23 of 30

10 votes 3 answers11k views
How many freeze-thaw cycles will survodutide at 5 mg/mL tolerate?

Conditions: survodutide · 5 mg/mL. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every batch, every…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

57 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
asked by meniscus_film 32k · 9 months ago
10 votes3 answers11k views
Is there any published stability data for a GLP-1 receptor agonist at 4 °C?

What I have: a GLP-1 receptor agonist · 4 °C. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the evidence…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
asked by net_peptide 12k · 14 months ago
10 votes 5 answers9.9k views
Is a wine cooler good enough for storing reconstituted dulaglutide?

Conditions: a wine cooler · dulaglutide. I would rather over-plan the first cycle and simplify later. I am prepared to do the work if someone can tell me which work…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
dulaglutide
dulaglutide

A once-weekly GLP-1 receptor agonist built on an Fc fusion rather than fatty-acid acylation. Use this tag for questions about the fusion-protein…

200 questions
asked by sinead_gaffney 28k · 9 months ago
10 votes 3 answers9.7k views
What happens to liraglutide after three weeks at minus 80 °C in solution?

For reference: liraglutide · three weeks · minus 80 °C. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
liraglutide
liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

235 questions
asked by Dr_Elias_Weiss 25k · 7 months ago
10 votes5 answers9.2k views
How long does tirzepatide stay within specification at minus 20 °C once reconstituted?

The specifics, since they change the answer: tirzepatide · minus 20 °C. I have read the obvious sources and they disagree with each other, so I would rather ask…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by tare_and_weigh 12k · 8 months ago
10 votes 5 answers8.7k views
Is there any published stability data for mazdutide at 40 °C?

What I have: mazdutide · 40 °C. I would rather be corrected now than propagate something wrong. I am specifically not interested in a testimonial; I am interested in…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
mazdutide
mazdutide

A GLP-1 and glucagon receptor dual agonist developed primarily in China, with a distinct dose range and a fast-moving publication record.…

237 questions
asked by fibre_or_fragment 13k · 3 months ago
10 votes4 answers7.4k views
Is there any published stability data for a GLP-1 receptor agonist at 30 °C?

Details up front: a GLP-1 receptor agonist · 30 °C. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
asked by sample_id 17k · 7 months ago
10 votes 5 answers7k views
Why does racemisation accelerate at 25 °C rather than proceeding linearly?

What I have: racemisation · 25 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I would still…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
asked by net_peptide 12k · 39 days ago
10 votes5 answers5.9k views
How many freeze-thaw cycles will dulaglutide at 20 mg/mL tolerate?

Stated plainly: dulaglutide · 20 mg/mL. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the theory. What I…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

57 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
dulaglutide
dulaglutide

A once-weekly GLP-1 receptor agonist built on an Fc fusion rather than fatty-acid acylation. Use this tag for questions about the fusion-protein…

200 questions
asked by nadia_kowalczyk 20k · 10 months ago
10 votes 1 answer5k views
What is the thermal exposure on a Changsha to New Zealand lane in summer?

Details up front: Changsha · New Zealand. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
asked by Dr_Ingrid_Baumgartner 73k · 3 months ago
10 votes 1 answer4.3k views
How long does a phase-change pack actually hold in a July transit lane?

Transit was eleven days with two scanning gaps, so the thermal history is partly inferred. I would like the arithmetic checked rather than the conclusion asserted. I…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
asked by thermal_mass 13k · 3 months ago
10 votes0 answers4.1k views
Is there any published stability data for retatrutide at 40 °C?

What I am working with: retatrutide · 40 °C. This is asserted often enough that I assumed it was established, and then I went looking for the source. I have searched…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
asked by lucia_marchetti 19k · 17 months ago
10 votes 5 answers3.8k views
What happens to ecnoglutide after twelve weeks at room temperature in solution?

The particulars: ecnoglutide · twelve weeks · room temperature. This is one of those things that everyone repeats and nobody derives. This matters practically, not…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
ecnoglutide
ecnoglutide

A long-acting GLP-1 receptor agonist with a cAMP-biased signalling profile. A niche tag, mostly used for mechanism questions about biased agonism…

223 questions
asked by lucia_marchetti 19k · 2 months ago
10 votes5 answers2.9k views
Is there any published stability data for liraglutide at 37 °C?

The particulars: liraglutide · 37 °C. Somebody stated this to me confidently and I would like to check it before repeating it. I would accept a well-reasoned negative…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
liraglutide
liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

235 questions
asked by jonas_ekstrom 12k · 37 days ago
10 votes 5 answers2.9k views
Is 4 °C an acceptable storage condition for lyophilised survodutide?

The particulars: 4 °C · survodutide. Somebody stated this to me confidently and I would like to check it before repeating it. I would accept a well-reasoned negative…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
asked by claudia_ferrante 22k · 3 months ago
10 votes0 answers2k views
Is there any published stability data for oral semaglutide at minus 20 °C?

The specifics, since they change the answer: oral semaglutide · minus 20 °C. Somebody stated this to me confidently and I would like to check it before repeating it.…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
oral-glp1
oral-glp1

Oral routes for GLP-1 receptor agonism: peptide formulations rescued by absorption enhancers such as SNAC, and true small molecules that need no…

219 questions
asked by syringe_ninety 12k · 5 days ago
9 votes 5 answers27k views
Is there any published stability data for tirzepatide at room temperature?

Stated plainly: tirzepatide · room temperature. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has tested that", I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by assay_blank 45k · 19 months ago
9 votes 5 answers25k views
How long does liraglutide stay within specification at 37 °C once reconstituted?

The particulars: liraglutide · 37 °C. I have read the obvious sources and they disagree with each other, so I would rather ask people who have actually done this. I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
liraglutide
liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

235 questions
asked by tobias_reint 20k · 20 months ago
9 votes 5 answers21k views
Does a GLP-1 receptor agonist adsorb measurably to the vial wall at 10 mg/mL?

What I have: a GLP-1 receptor agonist · 10 mg/mL. I can do the algebra. I am not confident about the conversion factors. If there is a standard way to lay this out, I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

476 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
asked by harriet_lonsdale 35k · 2.1 years ago
9 votes5 answers16k views
Why does racemisation accelerate at room temperature rather than proceeding linearly?

The specifics, since they change the answer: racemisation · room temperature. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
asked by imani_dube 8.9k · 17 months ago
9 votes 5 answers15k views
Why does racemisation accelerate at minus 20 °C rather than proceeding linearly?

Details up front: racemisation · minus 20 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
asked by marta_szymanska 10k · 2.1 years ago
9 votes 4 answers14k views
Does surface adsorption to the vial wall lose measurable peptide?

Transit was eleven days with two scanning gaps, so the thermal history is partly inferred. I would like the arithmetic checked rather than the conclusion asserted. I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

476 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
asked by oona_kekkonen 13k · 10 months ago
9 votes5 answers14k views
Does racemisation dominate for dulaglutide held at minus 80 °C?

What I have: racemisation · dulaglutide · minus 80 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
dulaglutide
dulaglutide

A once-weekly GLP-1 receptor agonist built on an Fc fusion rather than fatty-acid acylation. Use this tag for questions about the fusion-protein…

200 questions
asked by Dr_Fatima_Belkacem 18k · 18 months ago
9 votes2 answers13k views
Is there any published stability data for a GLP-1 receptor agonist at room temperature?

What I have: a GLP-1 receptor agonist · room temperature. I would rather be corrected now than propagate something wrong. I am specifically not interested in a…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
asked by swab_and_wait 13k · 22 months ago