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shelf-life

Page 6 of 13 · 301 questions tagged shelf-life.

301 questions · sorted by votes · page 6 of 13

21 votes 5 answers25k views
Is liraglutide at 4 mg/mL stable enough for four weeks of multi-withdrawal use?

The specifics, since they change the answer: liraglutide · 4 mg/mL · four weeks. Somebody stated this to me confidently and I would like to check it before repeating…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by dead_volume 49k · 15 months ago
21 votes 5 answers20k views
What happens to mazdutide after six weeks at 4 °C in solution?

Details up front: mazdutide · six weeks · 4 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by Dr_Fatima_Belkacem 52k · 22 months ago
21 votes 5 answers16k views
How long does oral semaglutide stay within specification at room temperature once reconstituted?

The particulars: oral semaglutide · room temperature. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer this than…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by pierce_count 15k · 16 months ago
21 votes2 answers15k views
What happens to dulaglutide after eight weeks at 25 °C in solution?

What I am working with: dulaglutide · eight weeks · 25 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious.…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by lucia_marchetti 18k · 16 months ago
21 votes2 answers11k views
Is 37 °C an acceptable storage condition for lyophilised a GLP-1 receptor agonist?

What I am working with: 37 °C · a GLP-1 receptor agonist. This is asserted often enough that I assumed it was established, and then I went looking for the source. I…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by sample_id 17k · 5 months ago
21 votes0 answers3.9k views
What happens to mazdutide after six weeks at 25 °C in solution?

Details up front: mazdutide · six weeks · 25 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by Dr_Ravi_Selvarajah 42k · 43 days ago
20 votes 5 answers37k views
What happens to retatrutide after two weeks at 4 °C in solution?

Setup, so nobody has to ask: retatrutide · two weeks · 4 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows,…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by eighty_six_hours 16k · 22 months ago
20 votes5 answers36k views
How long does ecnoglutide stay within specification at 37 °C once reconstituted?

The case in front of me: ecnoglutide · 37 °C. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already made one…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by mg_per_ml 12k · 19 months ago
20 votes 5 answers32k views
What happens to liraglutide after three weeks at 25 °C in solution?

The particulars: liraglutide · three weeks · 25 °C. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by cal_hennessy 14k · 18 months ago
20 votes 5 answers29k views
How long does dulaglutide stay within specification at minus 20 °C once reconstituted?

Stated plainly: dulaglutide · minus 20 °C. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am comfortable with…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by thabo_maseko 20k · 19 months ago
20 votes 5 answers29k views
Is room temperature an acceptable storage condition for lyophilised cagrilintide?

Setup, so nobody has to ask: room temperature · cagrilintide. This is asserted often enough that I assumed it was established, and then I went looking for the source.…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by leah_ferrers 15k · 2.1 years ago
20 votes5 answers17k views
How long does a GLP-1 receptor agonist stay within specification at 4 °C once reconstituted?

Numbers first: a GLP-1 receptor agonist · 4 °C. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked.…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by ayo_fadipe 19k · 17 months ago
20 votes 5 answers15k views
How long does survodutide stay within specification at 40 °C once reconstituted?

The case in front of me: survodutide · 40 °C. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already made one…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by juan_esquivel 14k · 19 months ago
20 votes 4 answers14k views
Is survodutide at 20 mg/mL stable enough for three weeks of multi-withdrawal use?

The case in front of me: survodutide · 20 mg/mL · three weeks. I want to know whether there is evidence behind this or only repetition. I have checked the obvious…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
endotoxin
endotoxin

Bacterial endotoxin: LAL and kinetic chromogenic methods, how an endotoxin limit is derived from a dose, why endotoxin survives autoclaving, and…

14 questions
asked by juan_esquivel 14k · 12 months ago
20 votes 5 answers13k views
Is ecnoglutide at 8 mg/mL stable enough for three weeks of multi-withdrawal use?

The case in front of me: ecnoglutide · 8 mg/mL · three weeks. I want to know whether there is evidence behind this or only repetition. I have checked the obvious…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by gel_pack_warm 13k · 2.0 years ago
20 votes 5 answers12k views
Is mazdutide at 4 mg/mL stable enough for two weeks of multi-withdrawal use?

What I have: mazdutide · 4 mg/mL · two weeks. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the evidence…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by ekaterina_volk 16k · 7 months ago
20 votes3 answers8.9k views
What happens to mazdutide after six weeks at 40 °C in solution?

What I have: mazdutide · six weeks · 40 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by anouk_desmet 18k · 5 months ago
20 votes4 answers7.5k views
Is semaglutide at 3.33 mg/mL stable enough for ten weeks of multi-withdrawal use?

Conditions: semaglutide · 3.33 mg/mL · ten weeks. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by leonid_marchuk 15k · 7 months ago
20 votes0 answers6.5k views
What happens to retatrutide after two weeks at 2–8 °C in solution?

Setup, so nobody has to ask: retatrutide · two weeks · 2–8 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by sample_id 17k · 10 months ago
20 votes 5 answers6.3k views
What happens to mazdutide after sixteen weeks at 25 °C in solution?

Details up front: mazdutide · sixteen weeks · 25 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by aine_mulcahy 35k · 5 months ago
19 votes5 answers36k views
How long does cagrilintide stay within specification at room temperature once reconstituted?

What I have: cagrilintide · room temperature. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked.…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by kirsi_lahtinen 45k · 21 months ago
19 votes 5 answers35k views
Is a GLP-1 receptor agonist at 2.5 mg/mL stable enough for eight weeks of multi-withdrawal use?

Numbers first: a GLP-1 receptor agonist · 2.5 mg/mL · eight weeks. I would rather be corrected now than propagate something wrong. I am specifically not interested in…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by pieter_maas 22k · 2.3 years ago
19 votes 5 answers28k views
How long does retatrutide stay within specification at 2–8 °C once reconstituted?

Stated plainly: retatrutide · 2–8 °C. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the theory. What I have…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by label_claim 11k · 14 months ago
19 votes0 answers13k views
How is a beyond-use date set for compounded dulaglutide in phosphate-buffered diluent?

Setup, so nobody has to ask: dulaglutide · phosphate-buffered diluent. This is a procedural question rather than a theoretical one, and I would like the procedure…

compounding
compounding

Compounded preparations: what a 503A and a 503B facility may legally prepare and when, base versus salt forms, beyond-use dating under USP…

61 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
bacteriostatic-water
bacteriostatic-water

Water for injection containing roughly 0.9 per cent benzyl alcohol as a bacteriostatic agent. It suppresses growth in a multiple-withdrawal vial;…

112 questions
asked by fill_volume 13k · 17 months ago