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nausea

Page 4 of 15 · 346 questions tagged nausea.

346 questions · sorted by votes · page 4 of 15

28 votes 2 answers35k views
What did the placebo arm of STEP 1 report for headache?

The specifics, since they change the answer: STEP 1 · headache. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
vomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

14 questions
asked by leonid_marchuk 15k · 22 months ago
28 votes 5 answers29k views
What did the placebo arm of SURMOUNT-4 report for constipation?

For reference: SURMOUNT-4 · constipation. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by label_claim 11k · 17 months ago
28 votes0 answers29k views
Is reflux on semaglutide dose-dependent or dose-rate dependent?

The particulars: reflux · semaglutide. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles that…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by low_dead_space 42k · 2.2 years ago
28 votes 5 answers28k views
What did the placebo arm of STEP 8 report for constipation?

What I have: STEP 8 · constipation. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by zeynep_arslan 20k · 21 months ago
28 votes 5 answers27k views
Does nausea at week ten of ecnoglutide usually resolve without a dose change?

Setup, so nobody has to ask: nausea · ten · ecnoglutide. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by anders_vestby 17k · 13 months ago
28 votes 5 answers24k views
What did the placebo arm of ATTAIN-1 report for reflux?

Concretely: ATTAIN-1 · reflux. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result, which I…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by yuki_morishita 19k · 8 months ago
28 votes0 answers18k views
Does fatigue at week three of mazdutide usually resolve without a dose change?

The particulars: fatigue · three · mazdutide. I have read the obvious sources and they disagree with each other, so I would rather ask people who have actually done…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by pieter_maas 22k · 14 months ago
28 votes4 answers17k views
Does constipation at week eight of orforglipron usually resolve without a dose change?

Concretely: constipation · eight · orforglipron. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by kwn_analytical 89k · 8 months ago
28 votes 5 answers16k views
Does holding at 20 mg for eight weeks before escalating reduce constipation?

What I am working with: 20 mg · eight weeks · constipation. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by coring_risk 17k · 16 months ago
28 votes 5 answers16k views
What did the placebo arms report for nausea, and why does that matter?

I have three data points across nine months, which I hope is enough to see a trend. This is presented as though it settles something, and I am not convinced it does.…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by u100_marks 38k · 10 months ago
28 votes 2 answers15k views
Is reflux on ecnoglutide dose-dependent or dose-rate dependent?

The particulars: reflux · ecnoglutide. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried to…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by mala_venkatesh 21k · 6 months ago
28 votes0 answers14k views
What is the reported incidence of early satiety on liraglutide in STEP 1?

Concretely: early satiety · liraglutide · STEP 1. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by swirl_dont_shake 19k · 13 months ago
28 votes5 answers11k views
Does dizziness at week five of liraglutide usually resolve without a dose change?

Numbers first: dizziness · five · liraglutide. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked.…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by felix_araya 17k · 12 months ago
27 votes 5 answers45k views
What did the placebo arm of ATTAIN-1 report for dizziness?

Conditions: ATTAIN-1 · dizziness. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics change…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by oona_kekkonen 16k · 20 months ago
27 votes3 answers39k views
What is the reported incidence of nausea on liraglutide in SURMOUNT-1?

The case in front of me: nausea · liraglutide · SURMOUNT-1. The figures are clear enough; the question is what they mean and what they do not. I can supply the…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by bea_castellanos 47k · 2.1 years ago
27 votes0 answers35k views
Does holding at 20 mg for two weeks before escalating reduce constipation?

What I am working with: 20 mg · two weeks · constipation. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious.…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by esben_lykke 15k · 2.4 years ago
27 votes 5 answers34k views
What is the reported incidence of headache on oral semaglutide in SURPASS-2?

The case in front of me: headache · oral semaglutide · SURPASS-2. The figures are clear enough; the question is what they mean and what they do not. I can supply the…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by rae_oyelowo 21k · 2.2 years ago
27 votes 4 answers32k views
What did the placebo arm of SELECT report for injection-site erythema?

The case in front of me: SELECT · injection-site erythema. I would like to know the limits of what can be inferred from this. What I am trying to avoid is…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by second_lot 11k · 2.2 years ago
27 votes0 answers27k views
What is the reported incidence of nausea on tirzepatide in SURMOUNT-2?

The case in front of me: nausea · tirzepatide · SURMOUNT-2. The figures are clear enough; the question is what they mean and what they do not. I can supply the…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by pk_curve 12k · 2.3 years ago
27 votes5 answers25k views
Does holding at 30 mg for sixteen weeks before escalating reduce reflux?

Details up front: 30 mg · sixteen weeks · reflux. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by tare_and_weigh 18k · 11 months ago
27 votes 5 answers24k views
Does holding at 8 mg for sixteen weeks before escalating reduce reflux?

What I have: 8 mg · sixteen weeks · reflux. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
vomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

14 questions
asked by imani_dube 19k · 12 months ago
27 votes 3 answers22k views
What is the reported incidence of dizziness on orforglipron in SURPASS-3?

Details up front: dizziness · orforglipron · SURPASS-3. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by sinead_gaffney 14k · 9 months ago
27 votes 5 answers21k views
Does holding at 2.5 mg for four weeks before escalating reduce hair thinning?

Concretely: 2.5 mg · four weeks · hair thinning. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by stopper_core 50k · 14 months ago
27 votes3 answers19k views
What did the placebo arm of FLOW report for vomiting?

Setup, so nobody has to ask: FLOW · vomiting. I have read the primary source rather than the summary, which has left me with more questions. I understand the…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by plate_count_9k 95k · 10 months ago