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coa

Page 27 of 32 · 749 questions tagged coa.

749 questions · sorted by votes · page 27 of 32

8 votes0 answers1.9k views
How many vials from a BCH lot should I send for peptide mapping?

Stated plainly: BCH · peptide mapping. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of magnitude and it…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
asked by void_volume 13k · 4 months ago
7 votes 5 answers21k views
What does 98.4% purity on a C18 column actually tell me about an ecnoglutide vial?

What I am working with: 98.4% · a C18 column · ecnoglutide. I would like help reading this properly rather than being told what conclusion to reach. I have the full…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by per_haugen 18k · 16 months ago
7 votes5 answers20k views
How do I reconcile 97.1% from VendorInvestigate with 98.4% from the supplier?

The case in front of me: 97.1% · VendorInvestigate · 98.4%. I have two candidate explanations and no way to distinguish them. The same procedure has worked without…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by imani_dube 19k · 16 months ago
7 votes 4 answers17k views
Does TFC issue lot-specific documentation, or a batch certificate?

The lot number on the vial matches the certificate, which at least rules out the easy problem. The figures are clear enough; the question is what they mean and what…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by meniscus_film 34k · 16 months ago
7 votes5 answers16k views
How do I read an ecnoglutide chromatogram from VendorInvestigate beyond the headline number?

Concretely: ecnoglutide · VendorInvestigate. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by ayo_fadipe 19k · 14 months ago
7 votes2 answers13k views
What does 98.8% purity on a C18 column actually tell me about an ecnoglutide vial?

What I am working with: 98.8% · a C18 column · ecnoglutide. I would like help reading this properly rather than being told what conclusion to reach. I have the full…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by sasha_ferreira 15k · 16 months ago
7 votes 5 answers11k views
How does WXT compare to ChinaPeptides (QYAOBIO) on documentation quality?

Stated plainly: WXT · ChinaPeptides (QYAOBIO). I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can obtain either…

vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by g_paskevicius 44k · 7 months ago
7 votes5 answers10k views
How does ERP compare to Nantong Guangyuan Chemical on documentation quality?

What I am working with: ERP · Nantong Guangyuan Chemical. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can…

vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by ayo_fadipe 19k · 13 months ago
7 votes 5 answers9.4k views
What does a method section on a CPC report change about how I read it?

The particulars: method section · CPC. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably comfortable…

coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by swab_and_wait 15k · 12 months ago
7 votes 5 answers6.7k views
What does a 98.2% purity with a batch certificate attached let me conclude?

Stated plainly: 98.2% · batch certificate. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline. I…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by mala_venkatesh 21k · 5 months ago
7 votes2 answers5.6k views
Would you re-test ecnoglutide after twelve weeks at room temperature, or accept the original certificate?

Conditions: ecnoglutide · twelve weeks · room temperature. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by per_haugen 18k · 6 months ago
7 votes 5 answers4.3k views
How does JEEP compare to Bachem Holding (Suzhou) on documentation quality?

Numbers first: JEEP · Bachem Holding (Suzhou). I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a defensible…

vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by jana_horakova 15k · 4 months ago
7 votes 5 answers4.1k views
What does a 97.9% purity with a sampling plan attached let me conclude?

Setup, so nobody has to ask: 97.9% · sampling plan. I would like help reading this properly rather than being told what conclusion to reach. I have the full report…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by aine_mulcahy 35k · 2 months ago
7 votes0 answers2.6k views
What does a list of related substances on a GL Biochem report change about how I read it?

The case in front of me: list of related substances · GL Biochem. The figures are clear enough; the question is what they mean and what they do not. I can supply the…

coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by retest_please 13k · 7 months ago
7 votes0 answers1.6k views
What does a Karl Fischer water content test add for oral semaglutide that a purity figure does not?

Concretely: a Karl Fischer water content test · oral semaglutide. These are treated as interchangeable and I do not think they are. If both are acceptable I would…

content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by cold_lane 14k · 2 months ago
7 votes0 answers1k views
What does a 95.2% purity with a purity figure attached let me conclude?

What I have: 95.2% · purity figure. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by eighty_six_hours 16k · 4 months ago
6 votes 5 answers24k views
What does identity confirmation by mass spectrometry add for survodutide that a purity figure does not?

The specifics, since they change the answer: identity confirmation by mass spectrometry · survodutide. I am trying to choose between two options that are usually…

content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by Dr_Wren_Halliday 40k · 21 months ago
6 votes 5 answers21k views
Would you re-test liraglutide after ten weeks at 30 °C, or accept the original certificate?

The particulars: liraglutide · ten weeks · 30 °C. I would like to define my thresholds before I have a result, for obvious reasons. I want a plan with explicit…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by tobias_reint 19k · 16 months ago
6 votes 5 answers18k views
How do I read an impurity table on an oral semaglutide certificate against the 95.2% headline?

For reference: oral semaglutide · 95.2%. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online calculator…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by jonas_ekstrom 18k · 2.2 years ago
6 votes 5 answers18k views
How do I write up a Medutest result on retatrutide so it is useful to others?

Details up front: Medutest · retatrutide. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked. Assume…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by Dr_Malik_Osei 37k · 22 months ago
6 votes 5 answers18k views
What does a 97.6% purity with a purity figure attached let me conclude?

Numbers first: 97.6% · purity figure. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by bufferline42 49k · 2.2 years ago
6 votes 5 answers17k views
Is an HPLC purity test on one vial from a five-person group buy enough for the whole split?

What I have: an HPLC purity test · a five-person group buy. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is…

group-buy
group-buy

Pooled purchasing: how the economics work, what trust structure a pool needs, splitting a single tested lot, and the failure modes when the…

41 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by mass_shift_18 14k · 2.1 years ago
6 votes 4 answers15k views
How does WWB compare to Bachem Holding (Suzhou) on documentation quality?

Numbers first: WWB · Bachem Holding (Suzhou). I have used one of these for a while and I am considering switching, which requires a reason. What I care about is…

vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by petra_hovland 42k · 2.4 years ago
6 votes5 answers15k views
How do I reconcile 97.9% from PeptideMeter with 99.1% from the supplier?

The particulars: 97.9% · PeptideMeter · 99.1%. Something has gone wrong and I would like to know how badly before I decide what to do. Nothing else in the setup…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by esther_vandeVelde 49k · 22 months ago