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Is triglycerides worth drawing at baseline before starting survodutide?

Asked 28 Apr 2026Modified 3 months agoViewed 3.6k times
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The particulars: triglycerides · survodutide.

I would like to define my thresholds before I have a result, for obvious reasons.

I want a plan with explicit stopping rules, not just steps.

What is the minimum version of this that is still defensible?

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askedilaria_bertone33k3828 Apr 2026

1 Answer

Accepted answer first, then by votes
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Accepted answer

Answer first: decide what you would do differently for each possible result before you order the panel. Anything that fails that test is a number you will worry about and not act on.

A twenty-analyte panel run on a healthy person will produce, on average, one out-of-range result purely from how reference intervals are constructed. That is arithmetic rather than pathology.

On the detail: a sensible core for this population is a full blood count, renal function with electrolytes, liver enzymes with bilirubin, a fasting lipid panel with apolipoprotein B, HbA1c and thyroid-stimulating hormone.

Reference intervals are conventionally the central ninety-five per cent of a reference population, which is the direct cause of the one-in-twenty out-of-range rate on a healthy panel.

The caveat is that a panel is not a diagnosis and interpreting one is a clinician's job, particularly when several values move together.

Baseline first, then a repeat under identical conditions. Everything else is secondary.

edited 15 May 2026 by Dr_Idris_Coulibaly — added the placebo-arm figures

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answered · acceptedDr_Idris_Coulibaly33k1373 May 2026
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