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titration

Page 6 of 19 · 444 questions tagged titration.

444 questions · sorted by votes · page 6 of 19

26 votes5 answers28k views
What does TRIUMPH-3 report at the 2 mg dose level?

Conditions: TRIUMPH-3 · 2 mg. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics change the…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by tamsin_wray 13k · 15 months ago
26 votes 3 answers24k views
Does holding at 10 mg for twelve weeks before escalating reduce early satiety?

The case in front of me: 10 mg · twelve weeks · early satiety. I want to know whether this is a real physical effect or an artefact of how it is measured. What…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by coldpack_88 37k · 18 months ago
26 votes0 answers17k views
Does holding at 5 mg for two weeks before escalating reduce early satiety?

Stated plainly: 5 mg · two weeks · early satiety. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by per_haugen 18k · 13 months ago
26 votes0 answers13k views
What does ATTAIN-1 tell me about hair thinning at the 50 mg dose?

What I have: ATTAIN-1 · hair thinning · 50 mg. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by Dr_Hanne_Solberg 40k · 8 months ago
26 votes1 answer11k views
Does vomiting at week nine of cagrilintide usually resolve without a dose change?

The particulars: vomiting · nine · cagrilintide. I have read the obvious sources and they disagree with each other, so I would rather ask people who have actually…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by fresh_bac 13k · 5 months ago
26 votes 5 answers11k views
What does SURPASS-3 tell me about early satiety at the 8 mg dose?

For reference: SURPASS-3 · early satiety · 8 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by lukas_sedlacek 17k · 14 months ago
26 votes0 answers11k views
Is early satiety on mazdutide dose-dependent or dose-rate dependent?

Setup, so nobody has to ask: early satiety · mazdutide. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by valentina_rossi 16k · 19 months ago
25 votes5 answers43k views
Does early satiety at week six of orforglipron usually resolve without a dose change?

The case in front of me: early satiety · six · orforglipron. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by kirsi_lahtinen 45k · 2.1 years ago
25 votes 5 answers40k views
What does STEP 1 report at the 50 mg dose level?

Setup, so nobody has to ask: STEP 1 · 50 mg. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline.…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by lucia_marchetti 18k · 17 months ago
25 votes4 answers33k views
Does early satiety at week six of survodutide usually resolve without a dose change?

What I am working with: early satiety · six · survodutide. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by ahmed_zerouali 19k · 14 months ago
25 votes 5 answers28k views
Is a titration interval of ten weeks better supported than four weeks for a GLP-1 receptor agonist?

What I am working with: ten weeks · a GLP-1 receptor agonist. This has the shape of a fact but I cannot find its origin. What I found instead were three secondary…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by claudia_ferrante 46k · 17 months ago
25 votes5 answers23k views
What did ATTAIN-1 do with participants who could not tolerate a step?

I am asking about the protocol logic rather than about my own case specifically. I want to understand what this actually establishes, as opposed to what it is being…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by lucia_marchetti 18k · 10 months ago
25 votes 5 answers16k views
Does holding at 8 mg for sixteen weeks before escalating reduce injection-site erythema?

Details up front: 8 mg · sixteen weeks · injection-site erythema. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by swab_and_wait 15k · 4 months ago
25 votes 5 answers16k views
What does FLOW tell me about injection-site erythema at the 10 mg dose?

What I am working with: FLOW · injection-site erythema · 10 mg. I have read the primary source rather than the summary, which has left me with more questions. I…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by jana_horakova 15k · 7 months ago
25 votes 4 answers15k views
What does PIONEER-4 tell me about headache at the 2 mg dose?

The specifics, since they change the answer: PIONEER-4 · headache · 2 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by ravenna_pace 13k · 7 months ago
25 votes4 answers13k views
Why is the titration interval four weeks and not two?

The label documentation for the agent in question is ambiguous on exactly this point. This is one of those things that everyone repeats and nobody derives. This…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
amylin
amylin

Amylin and its analogues, most prominently cagrilintide, as a satiety mechanism orthogonal to incretin signalling. Includes the pharmacology of…

14 questions
asked by Dr_Colm_Fitzhenry 85k · 11 months ago
25 votes 5 answers13k views
Does constipation at week four of dulaglutide usually resolve without a dose change?

The case in front of me: constipation · four · dulaglutide. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
injection-site-reaction
injection-site-reaction

Local reactions: erythema, induration, pruritus and nodules. Their relationship to injection depth, diluent composition, benzyl alcohol…

14 questions
asked by tri_gly_ala 48k · 4 months ago
25 votes0 answers9.5k views
What does STEP 4 tell me about fatigue at the 5 mg dose?

Conditions: STEP 4 · fatigue · 5 mg. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
injection-site-reaction
injection-site-reaction

Local reactions: erythema, induration, pruritus and nodules. Their relationship to injection depth, diluent composition, benzyl alcohol…

14 questions
pcos
pcos

Polycystic ovary syndrome: insulin resistance as the shared mechanism, ovulatory and menstrual outcomes reported on treatment, androgen changes,…

14 questions
asked by cake_collapsed 13k · 13 months ago
25 votes5 answers8.4k views
What does SURMOUNT-5 report at the 40 mg dose level?

What I have: SURMOUNT-5 · 40 mg. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree, which…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by kirsi_lahtinen 45k · 7 months ago
25 votes 1 answer5.9k views
What does TRIUMPH-3 report at the 5 mg dose level?

The particulars: TRIUMPH-3 · 5 mg. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am being…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by marta_szymanska 17k · 6 months ago
24 votes5 answers50k views
What did PIONEER-4 do with participants who could not tolerate a step?

I am asking about the protocol logic rather than about my own case specifically. I want to understand what this actually establishes, as opposed to what it is being…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by one_ml_bac 12k · 23 months ago
24 votes 5 answers43k views
What does SELECT tell me about early satiety at the 4 mg dose?

Details up front: SELECT · early satiety · 4 mg. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by cap_the_luer 15k · 23 months ago
24 votes 5 answers38k views
Does dizziness at week seven of a GLP-1 receptor agonist usually resolve without a dose change?

For reference: dizziness · seven · a GLP-1 receptor agonist. I have read the obvious sources and they disagree with each other, so I would rather ask people who have…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by meniscus_film 34k · 2.3 years ago
24 votes0 answers23k views
Does vomiting at week three of tirzepatide usually resolve without a dose change?

What I have: vomiting · three · tirzepatide. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by coring_risk 17k · 2.2 years ago