PeptideStack
5.2kquestions
20kanswers
220users

glp1-mechanism

Page 8 of 8 · 175 questions tagged glp1-mechanism.

175 questions · sorted by votes · page 8 of 8

2 votes5 answers3.2k views
What does the mechanism of oral semaglutide predict that SURMOUNT-OSA did not test?

The particulars: oral semaglutide · SURMOUNT-OSA. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by swirl_dont_shake 19k · 37 days ago
2 votes 5 answers2.9k views
What does the mechanism of oral semaglutide predict that TRIUMPH-3 did not test?

For reference: oral semaglutide · TRIUMPH-3. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by jana_horakova 15k · 6 months ago
2 votes0 answers931 views
What does the mechanism of mazdutide predict that SELECT did not test?

Numbers first: mazdutide · SELECT. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how confident…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by fiadh_cronin 14k · 3 months ago
1 vote5 answers7k views
What does the mechanism of semaglutide predict that SURMOUNT-5 did not test?

Conditions: semaglutide · SURMOUNT-5. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is an…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by h_pergande 86k · 8 months ago
1 vote 3 answers3.7k views
What does the mechanism of retatrutide predict that STEP 1 did not test?

What I am working with: retatrutide · STEP 1. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

14 questions
asked by orla_ferriter 47k · 9 months ago
1 vote3 answers3.2k views
Does splitting a 20 mg weekly dose of mazdutide across two administrations change anything?

What I am working with: 20 mg · mazdutide. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would rather…

split-dosing
split-dosing

Dividing a weekly dose across more than one administration. Questions here concern the pharmacokinetic rationale, whether the peak-to-trough ratio…

39 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

14 questions
asked by pk_curve 12k · 7 months ago
1 vote 5 answers2.7k views
Does splitting a 2.5 mg weekly dose of tirzepatide across two administrations change anything?

Concretely: 2.5 mg · tirzepatide. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically, because it…

split-dosing
split-dosing

Dividing a weekly dose across more than one administration. Questions here concern the pharmacokinetic rationale, whether the peak-to-trough ratio…

39 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
asked by Dr_Sara_Kuusela 46k · 4 months ago