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gi-side-effects

Page 3 of 18 · 416 questions tagged gi-side-effects.

416 questions · sorted by votes · page 3 of 18

32 votes 4 answers17k views
Does constipation at week six of retatrutide usually resolve without a dose change?

Conditions: constipation · six · retatrutide. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already made one…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by jo_vandeberg 19k · 17 months ago
32 votes0 answers12k views
What did the placebo arm of STEP 2 report for nausea?

For reference: STEP 2 · nausea. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am being…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by sasha_ferreira 15k · 12 months ago
31 votes 4 answers30k views
What does SUSTAIN-6 tell me about reflux at the 10 mg dose?

Setup, so nobody has to ask: SUSTAIN-6 · reflux · 10 mg. I have read the primary source rather than the summary, which has left me with more questions. I understand…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by ines_brandt 93k · 2.1 years ago
31 votes5 answers25k views
What did the placebo arm of SURMOUNT-2 report for reflux?

Stated plainly: SURMOUNT-2 · reflux. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline. I do…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by area_percent 13k · 2.1 years ago
31 votes0 answers23k views
Is early satiety on a GLP-1 receptor agonist dose-dependent or dose-rate dependent?

Setup, so nobody has to ask: early satiety · a GLP-1 receptor agonist. The empirical answer seems settled. The explanation does not. If the honest answer is that…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by ivo_paunovic 15k · 12 months ago
31 votes 5 answers22k views
When does constipation stop being a tolerability issue and become a clinical one?

I am comparing three suppliers on documentation rather than on price. I am trying to build something sustainable rather than something thorough that I will abandon. I…

harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
pancreatitis
pancreatitis

Acute pancreatitis as a labelled risk: background incidence, the signal in pooled trial and pharmacovigilance data, lipase interpretation, and the…

14 questions
asked by p_mkhize 41k · 21 months ago
31 votes 5 answers20k views
Does early satiety at week six of retatrutide usually resolve without a dose change?

The case in front of me: early satiety · six · retatrutide. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
pancreatitis
pancreatitis

Acute pancreatitis as a labelled risk: background incidence, the signal in pooled trial and pharmacovigilance data, lipase interpretation, and the…

14 questions
asked by tri_gly_ala 48k · 21 months ago
31 votes 5 answers19k views
What does SURMOUNT-1 tell me about headache at the 50 mg dose?

What I have: SURMOUNT-1 · headache · 50 mg. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

14 questions
asked by tess_amankwah 48k · 14 months ago
31 votes 5 answers17k views
Does reflux at week five of oral semaglutide usually resolve without a dose change?

Details up front: reflux · five · oral semaglutide. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by ben_akintola 14k · 10 months ago
31 votes5 answers17k views
Does vomiting at week twelve of oral semaglutide usually resolve without a dose change?

Numbers first: vomiting · twelve · oral semaglutide. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by Dr_Ingrid_Baumgartner 39k · 15 months ago
31 votes 5 answers15k views
What does STEP 1 tell me about dizziness at the 10 mg dose?

Stated plainly: STEP 1 · dizziness · 10 mg. I would like help reading this properly rather than being told what conclusion to reach. I have the full report including…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by w_okoye 40k · 10 months ago
31 votes4 answers14k views
What did SURMOUNT-3 do with participants who could not tolerate a step?

I have been on a stable schedule for eleven weeks, so this is not a first-week question. I can parse the result. I am less sure what it licenses me to conclude. I…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by elke_brunner 14k · 13 months ago
31 votes 2 answers11k views
Is early satiety on liraglutide dose-dependent or dose-rate dependent?

Conditions: early satiety · liraglutide. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically,…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by grainne_ahearn 13k · 10 months ago
30 votes 5 answers56k views
Is vomiting on survodutide dose-dependent or dose-rate dependent?

For reference: vomiting · survodutide. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles that…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by dana_wexler 15k · 2.2 years ago
30 votes 5 answers55k views
What is the reported incidence of reflux on orforglipron in STEP 3?

What I have: reflux · orforglipron · STEP 3. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by ivo_paunovic 15k · 22 months ago
30 votes 5 answers45k views
What did the placebo arm of STEP 3 report for hair thinning?

For reference: STEP 3 · hair thinning. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

14 questions
asked by zainab_mustafa 16k · 2.0 years ago
30 votes5 answers27k views
What does PIONEER-1 tell me about nausea at the 30 mg dose?

The particulars: PIONEER-1 · nausea · 30 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by label_claim 11k · 2.2 years ago
30 votes3 answers25k views
What is the reported incidence of fatigue on semaglutide in PIONEER-4?

The specifics, since they change the answer: fatigue · semaglutide · PIONEER-4. I want to understand what this actually establishes, as opposed to what it is being…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by fibre_or_fragment 12k · 17 months ago
30 votes 5 answers23k views
Is dizziness on ecnoglutide dose-dependent or dose-rate dependent?

The particulars: dizziness · ecnoglutide. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried to…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by dead_volume 49k · 22 months ago
30 votes 5 answers23k views
What is the reported incidence of fatigue on semaglutide in STEP 5?

For reference: fatigue · semaglutide · STEP 5. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by ahmed_zerouali 19k · 12 months ago
30 votes 5 answers23k views
When does fatigue stop being a tolerability issue and become a clinical one?

The lane and the lead time matter as much as the material for what I am doing. I would rather over-plan the first cycle and simplify later. I am prepared to do the…

harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
pancreatitis
pancreatitis

Acute pancreatitis as a labelled risk: background incidence, the signal in pooled trial and pharmacovigilance data, lipase interpretation, and the…

14 questions
asked by charge_state_3 39k · 9 months ago
30 votes5 answers20k views
What did the placebo arm of SURMOUNT-3 report for reflux?

The case in front of me: SURMOUNT-3 · reflux. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by aine_mulcahy 35k · 13 months ago
30 votes 5 answers17k views
What did the placebo arm of REDEFINE-1 report for reflux?

What I am working with: REDEFINE-1 · reflux. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline.…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by swirl_dont_shake 19k · 10 months ago
30 votes 3 answers16k views
What is the reported incidence of hair thinning on mazdutide in FLOW?

Setup, so nobody has to ask: hair thinning · mazdutide · FLOW. I would like help reading this properly rather than being told what conclusion to reach. I have the…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by lipid_panel_q 44k · 11 months ago