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Would a Karl Fischer water content test distinguish deamidation from a synthesis impurity in dulaglutide?

Asked 3 Oct 2025Modified 10 months agoViewed 1.4k times
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Conditions: a Karl Fischer water content test · deamidation · dulaglutide.

I would like the axes of comparison first and the recommendation second.

I have tried the first option and it works; the question is whether the second is better rather than merely different.

Under what conditions does the answer flip?

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askedmira_sundqvist19k183 Oct 2025
7This is the first explanation of that which has actually made sense to me. – wren_calloway 7 months ago
8Note that the label instructions differ between agents on precisely this point. – Dr_Wren_Halliday 9 months ago
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